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Martin Parker

Martin's office is on Level 8 of the Astbury Building.

Welcome to Martin Parker, who has recently taken up an appointment as a University Research Fellow. Martin's group (PhD student Geraint Thomas and RA Marc Aulton-Jones) is focussed on computational and experimental studies of protein folding.

Leeds now houses one of the largest Virology groups in the UK and the third Leeds Virology Daywas held on Friday 7th November. It was attended by 60 delegates - many of whom are members of the Astbury Centre. The event was organised by Julian Hiscox and Nicola Stonehouse and was made possible by the generous support given by Helena Biosciences, Invitrogen, Replizyme and Sigma.

Jenny Gilmartin has taken on a new role within the Faculty of Biological Sciences and has now ceased acting as administrative assitant within Astbury. Jenny has made outstanding contributions to the work of the Centre over the last few years.

We will miss her but wish her well in her new role!

WT dinner To celebrate our Wellcome Trust PhD programme, a dinner was held on October 6th for students and supervisors in University House. The meal was followed by a lively general knowledge quiz. Many thanks to Alan Berry for organising the evening!
WT dinner WT dinner

Venki Ramakrishnan from the LMB in Cambridge visited the Faculty on October 1st and gave an excellent seminar on his work on the 30s ribosome. The visit was sponsored by the BMB seminar series.

Venki Ramakrishnan and Simon Phillips

Nicola Stonehouse and Peter Stockley attended the Fourth International Virus Assembly Symposium at the end of September. It was an excellent opportunity to meet up with collaborators (Kaspars Tars from Uppsala and Tianwei Tin from Scripps are pictured) and hear excellent science in rather nice surroundings!

Tianwei Lin
Kaspars Tars sardinia

Congratulations to us!

Members of the Centre are heavily involved in the Wellcome Trust 4 year PhD programme and we are happy to announce that the application to extend the programme has been successful, to the tune of 5 students per year for the next 5 years. The panel was very impressed with the management of our programme, its interdisciplinary nature and the quality of our students.

And Congratulations...

... to Steve Griffin of the Harris group on winning the Young Microbiologist of the Year Award. The competition was held at the Society for General Microbiology meeting in September and this is the second year runninmg that a member of the gruoip has won the award. Last year it was presented to Andrew Macdonald.

bbq

The Astbury barbeque was held on September 17th. It was attended by over 70 members of the Centre and a good time was had by all!

Many thanks to those whose hard work helped to make the event such a success.

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The event was also attended by Kevin Plaxco from UCSB (pictured centre in the white T shirt), who was visiting Sheena Radford's lab.

Kevin Plaxco

Congratulations to...

Stephen Lane, from the Phillips group, who had his PhD viva on June 30th

Viva
The NESBIC poster session

The 4th annual NESBIC symposium was held in Leeds on June 27th. The programme included a series of excellent presentations followed by a lively poster session, where the following prizes were awarded:

First Prize of £50 from GlaxoSmithKline to
Mr Stephen Muench, Sheffield
'Novel insights into the design of antimalarial agents from the structure of Plasmodium falciparum enoyl reductase'

3 runner up prizes of £20 each to:
Dr Michael Sherrett, Manchester
'Determining Young's modulus for an isolated supra-molecular assembly'
Ms Rhoda Hawkins, Dept Physics & Astronomy, Leeds
'A simple model of entropic allostery'
Ms Nicoletta Kokkoni, UMIST
'Structural studies on N-methylated derivatives of Alzheimer's Aß (25-35) by solution-state NMR'

The NESBIC poster session The NESBIC poster session

The new JIF Centre for Biomolecular Interactions is on Level 9 of the Astbury Building...

9.105 Computer Cluster, Don Akrigg x37272
9.106 Surfact Plasmon Resonance, Andy Baron x37271 & 37278
9.107 Mass Spectrometry, Alison Ashcroft x37273 & 37275
9.108 Main lab (HPLC, amino acid analysis, protein purification, oligonucleotide synthesis, peptide synthesis) Chris Adams x37279, 37276 and Andrea Coates x37276 & 37278
9.108 Analytical Ultracentrifuge, Andy Baron x37276, 37278
9.108 Stopped flow calorimetry, ChrisAdams & Andy Baron x37277

Level 9
The new lab

Welcome to two new post-doctoral fellows...

Mark Robinson, in the Stonehouse Group and Gabriel Uguru working with Kenny McDowall and Simon Baumberg.

The Stonehouse and McDowall groups have now moved into newly redecorated labspace, shared with the Baumberg group. They can be found in 10.17 on Level 10 of the Manton Building (tel: 33089 or 33106).

Mark Robinson Gabriel Uguru

Peter Stockley and Simon Phillips have co-authored an article in the April issue of The Biochemist, celebrating 50 years of the double helix. The article highlights advances since the first X-ray diffraction photographs of DNA were taken by W.T. Astbury in Leeds in 1928.

The cover of The Biochemist

After many years at the University working with Peter Stockley, Nic Stonehouse and Alastair Smith, Hugo Lago leaves next week to take up a post in the Scripps Institute, San Diego, USA.

The place won't be the same without him!

More pictures

Peter
The 2003 Royal Society Bakerian Lecture was held in Leeds on 13th March. Chris Dobson gave an superb account of his work on Protein Folding and Misfolding and also spend time with students and post-docs from the faculty at a poster session. Chris Dobson at the poster session

Congratulations to Alastair Smith and Kenny McDowall on promotion to Reader and Senior Research Fellow respectively.

The poster session Matt Walker and Peter Knight with their Nature Cover
The 2003 Structural Biology Evening was held on 13th February. An excellent programme of talks was followed by a wine and posters reception, sponsored by Biochemistry and Molecular Biology.
Yulia Redko and Ferenc Marincs Gavin Williams, Peter Stockley, David Brockwell and Bruce Turnbull

Scientific session chaired by Sheena Radford

Yulia Redko - Determinants of RNA cleavage by E.coli RNase E, the key enzyme of RNA decay

Gavin Williams - Directed evolution of aldolases

Ferenc Marincs - Microarray analyses of gene expression in E.coli

Caitriona Dennis - Biophysical analysis on HIV-1 Nef

Bruce Turnbull - Dissecting the cholera toxin-ganglioside GM1 interaction by ITC

David Brockwell - Characterisation of mechanical resistance in proteins using AFM

Peter Stockley - Concluding remarks

wine

Congratulations...

to Stan Burgess, Matt Walker and Peter Knight on their paper on Dynein in Nature. Not only is the paper outstanding, but it is also featured on the cover of the February 13th issue.

Nature cover picture
Sheena Radford and Bill Ashraf

Welcome...

to Bill Ashraf who has recently joined Sheena Radford's lab following the award of a Leverhulme Trust Fellowship.

Alastair Smith and Sheena Radford with an AFM

AFM in the news...

Alastair Smith and Sheena Radford's work on Atomic Force Microscopy is highlighted in an article in the Reporter issue 484.

Congratulations...

...to Andrew Macdonald of the Harris group on winning the Promega Young Microbiologist of the Year Award and a cheque for £600. The competition was held at the Society for General Microbiology meeting on September 17th.

Members of the Astbury Centre enjoyed celebrations to mark the official retirement of Professor David Cove from the Chair of Genetics here in Leeds. A symposium in honour of David's retirement 'From Aspergillus to Physcomitrella and beyond' was held on September 17th, followed by a dinner at the Royal Armories. A good time was had by all, although we have no photographic evidence at the present time!

Adam Nelson has been honoured with the 2002 Pfizer academic award. It is awarded annually to young European medics, biologists or chemists, and comes with a £12k contribution towards the award holder's research.

It was awarded to Adam for "the first desymmetrisation of a centrosymmetric molecule in natural product synthesis and for elegant use of two-directional synthetic strategies". These tactics are both ways that improve the synthetic efficiency by exploiting the hidden symmetry of target molecules.

Adam Nelson and Simon Phillips

Congratulations...

...to Adam Nelson and Simon Phillips who have both been honoured with awards from the Royal Society of Chemistry.
Simon has been presented with the Award for Peptides and Proteins sponsored by
AstraZeneca. Adam was awarded the Meldola medal for the best independent research by an organic or inorganic chemist under 30 for his work on stereochemistry and bioactive
natural product synthesis.

David Smith, Christine Hilcenko and Chi Trinh

The third annual NESBIC symposium...
was held in Sheffield on July 2nd. The meeting was attended by particiants from Leeds, Manchester and Sheffield as well as Julia Goodfellow from the BBSRC, who presented cash prizes for the best poster. This went to Christine Hilcenko with Chi Trinh and David Smith collecting a runner-up prize.

Participants at the Knowles Symposium

A Symposium to celebrate the work of Professor Peter Knowles...

was held in the Astbury Centre on April 22nd

Before the Symposium, the invited international speakers enjoyed a weekend in the Dales!

Participants at the Knowles Symposium  
Participants at the Knowles Symposium  

Congratulations...

...to Andy Capaldi and Sheena Radford on their paper on the folding of Im7, published in the March issue of Nature Structural Biology.

Following Steph Capaldi's successful PhD viva last month, Andy and Steph have now moved to San Francisco.

National Science Week - two honored guests!

The University was visited by Prof Lord Robert Winston and Dr Tim Hunt FRS. Prof Winston was invited by the Union Biochemistry Society. He gave a lecture entitled 'Laundering Genes - is genetic science bad for us?' on Monday 11th March and also attended the Society's Annual Dinner.
Dr Tim Hunt FRS, Nobel laureate officially opened the New Garstang Teaching Laboratories on March 13th and presented an entertaining seminar, describing his experiments on the cell cycle that led to the award of a Nobel Prize last year.

Richard Jackson Welcome... to Richard M. Jackson - new Lecturer in Bioinformatics
New postgraduate students

Welcome... to the new Astbury postgraduate students!
Some of 24 new students are pictured above

The first Structural Biology Evening ...research talks followed by posters and wine... was held on September 20th Adam Nelson
Neil Thomson Nicola Stonehouse
Andrew Capadli Alexander Giesen

Congratulations...

Jo Jäger and Janice Pata were married on August 18th at Janice's home in Stoney Creek, Conneticut

JJ and Janice Pata's wedding
JJ and Janice Pata's wedding JJ and Janice Pata's wedding

The University of Leeds hosted a lecture by the 2001 Feldberg Foundation award winner, Prof Wolfgang Baumeister, Director of the Max-Planck Institute for Biochemistry, in Martinsried, Germany. As part of the award, the winner presents up to 3 lectures in UK Universities of his choice, so we are delighted he has chosen Leeds.

His lecture was on Tuesday 16th October, entitled The 26S proteasome: a molecular machine designed for controlled proteolysis.

Steph Fonseca and Andy Capaldi's wedding

Congratulations...

Steph Fonseca and Andy Capaldi of the Stonehouse and Radford groups respectively, who were married in August in London.

Steph Fonseca and Andy Capaldi's wedding Steph Fonseca and Andy Capaldi's wedding
Steph Fonseca and Andy Capaldi's wedding
HCV polymerase

Hepatitis C virus polymerase is featured in the Leeds Reporter - focusing on the work of Joe Jäger's and Dave Rowlands' groups.

HCV

Congratulations to...

Wilf Horn for winning the runner up prize at the British Crystallography Meeting for his poster 'Structural determination of an RNA translational operator incorporating 2'-deoxy-2-aminopurine complexed with bacteriophage MS2 coat protein'.

Wilf's prize was presented by Siân Rowsell.

Wilf Horn

New Head of the Astbury Centre...

Peter Stockley is the new Director of the Centre, with Steve Homans as Deputy. Simon Phillips has become the new Dean for Research in the Faculty of Biological Sciences.

Peter Stockley
JIF Centre opening

New £8 million Centre for Biomolecular Interactions!

Members of the Astbury Centre have been successful with a £8 million bid for a new centre that will establish Leeds as one of the world's leading players in the exciting scientific areas of understanding the "book of life" represented by the human genome sequence.

Opening of Protein Chemistry Facility

The official opening of the JREI-funded Protein Chemistry Facility was held on Monday 15th January. For more information, see the Facilities pages.

JREI
Jeff Keen Jeff Keen - protein sequencing
Alison and Andy

Alison Ashcroft - Mass Spectrometry

Andy Baron - Analytical Ultracentrifugation and SPR

andrea Andrea Coates - Peptide Synthesis and Amino Acid Analysis (with Chris Adams)
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