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Prof Simon Phillips

Simon Phillips was Astbury Professor of Biophysics in the Astbury Centre for Structural Molecular Biology from 1996 until 2008. In 2008, he became the first Director of the Research Complex at Harwell. He obtained his B.Sc. and Ph.D. in Chemistry from University College London in 1971 and 1974. He joined the academic staff of the University of Leeds in 1986 following postdoctoral work at the University of British Columbia (Canada) and staff scientist positions at the MRC Laboratory of Molecular Biology (Cambridge) and the Institut Pasteur (Paris). Simon is a Visiting Professor at the University of Leeds, and maintains his links with the Astbury Centre for Structural Molecular Biology as a Visiting Member.

Research Areas:

Publications from the last 5 years:

2010

2009

2008

Dunsmore, C; Miller, K; Blake, KL; Patching, SG; Henderson, PJF; Garnett, JA; Stubbings, WJ; Phillips, SEV; Palestrant, DJ; De Los Angeles, J; Leeds, JA; Chopra, I; Fishwick, CWG (2008) 2-Aminotetralones: Novel inhibitors of MurA and MurZ. Bioorganic And Medicinal Chemistry Letters 18(5), 1730-1734

Garnett, JA; Marincs, F; Baumberg, S; Phillips, SEV; Stockley, PG (2008) Structure and function of the arginine repressor-operator complex from Bacillus subtilis. Journal of Molecular Biology 379(2), 284-298

2007

Garnett, JA; Baumberg, S; Stockley, PG; Phillips, SEV (2007) A high-resolution structure of the DNA-binding domain of AhrC, the arginine repressor/activator protein from Bacillus subtilis. Acta Crystallographica. Section F, Structural Biology And Crystallization Communications 63(11), 914-917

Knowles, P; Kurtis, C; Murray, J; Saysell, C; Tambyrajah, W; Wilmot, CM; McPherson, MJ; Phillips, SEV; Dooley, DM; Brown, D; Rogers, M; Mure, M (2007) Hydrazine and amphetamine binding to amine oxidases: old drugs with new prospects . Journal of Neural Transmission (budapest) 114(6), 743-746

Syme, NR; Dennis, C; Phillips, SEV; Homans, SW (2007) Origin of heat capacity changes in a "Nonclassical" hydrophobic interaction . Chembiochem 8(13), 1509-1511

Garnett, JA; Baumberg, S; Stockley, PG; Phillips, SEV (2007) Structure of the C-terminal effector-binding domain of AhrC bound to its corepressor L-arginine. Acta Crystallographica. Section F, Structural Biology And Crystallization Communications 63(11), 918-921

Trinh, CH; Liu, Y; Phillips, SEV; Phillips-Jones, MK (2007) Structure of the response regulator VicR DNA-binding domain. Acta Crystallographica. Section D: Biological Crystallography 63, 266-269

Rogers, MS; Tyler, EM; Akyumani, A; Kurtis, CR; Spooner, RK; Deacon, SE; Tamber, S; Firbank, SJ; Mahmoud, K; Knowles, PF; Phillips, SEV; McPherson, MJ; Dooley, DM (2007) The stacking tryptophan of galactose oxidase: A second-coordination sphere residue that has profound effects on tyrosyl radical behavior and enzyme catalysis . Biochemistry 46(15), 4606-4618

Hadden, JM; Declais, AC; Carr, SB; Lilley, DMJ; Phillips, SEV (2007) The Structural Basis of Holliday Junction Resolution by T7 Endonuclease I.. Nature 449(7162), 621-624

2006

Carr, SB; Makris, G; Phillips, SEV; Thomas, CD (2006) Crystallization and preliminary X-ray diffraction analysis of two N-terminal fragments of the DNA-cleavage domain of topoisomerase IV from Staphylococcus aureus. Acta Crystallographica. Section F, Structural Biology And Crystallization Communications 62(11), 1164-1167

Horn, WT; Tars, K; Grahn, E; Helgstrand, C; Baron, AJ; Lago, H; Adams, CJ; Peabody, DS; Phillips, SEV; Stonehouse, NJ; Liljas, L; Stockley, PG (2006) Structural Basis of RNA Binding Discrimination between Bacteriophages Qβ and MS2 . Structure 14(3), 487-495

Bingham, RJ; Dive, V; Phillips, SEV; Shirras, AD; Isaac, RE (2006) Structural diversity of angiotensin-converting enzyme - Insights from structure-activity comparisons of two Drosophila enzymes . Febs Journal 273(2), 362-373

Barratt, E; Bronowska, A; Vondrasek, J; Cerny, J; Bingham, RJ; Phillips, SEV; Homans, SW (2006) Thermodynamic penalty arising from burial of a ligand polar group within a hydrophobic pocket of a protein receptor . Journal of Molecular Biology 362(5), 994-1003

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