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The Astbury Centre for Structural Molecular Biology
Annual report 2006
INDEX TO THE 2006 REPORT
The full 2006 report can be downloaded as an 20.5MB pdf file
here
.
Individual reports can be downloaded as pdf files using the links below
Director's statement for 2006
Download
Alison Ashcroft
♦
Mass spectrometry research group & facility
♦
Applications of synthetic organic chemistry to biological problems
♦
Investigating fibril structure and assembly using mass spectrometry
♦
Determining the mechanism of bacterial fibre assembly using non-covalent electrospray ionisation mass spectrometry
♦
Assembly of ssRNA viruses: The role(s) of the package during packaging.
Alan Berry
♦
Directed evolution of new enzyme activities
David Brockwell
♦
Mechanical unfolding of proteins using dynamic force spectroscopy
Stan Burgess
♦
Structural studies of the motor protein dynein
Thomas Edwards
♦
Solution structure of the Vts1 SAM domain bound to RNA
John Findlay
♦
Lipocalin receptors
Mark Harris
♦
Studies on the functions of hepatitis C virus proteins
♦
Studies on the HIV-1 Nef protein
Peter Henderson
♦
Electrodes for redox-active membrane proteins
♦
In vitro
studies of sensor kinase and response regulator proteins of the Prr two-component signal transduction pathway in
Rhodobacter sphaeroides
Julian Hiscox
♦
Development of a herpesvirus-based bionanosubmarine
Steve Homans
♦
The contributions of backbone protein dynamics and ligand reorientation to the thermodynamics of ligand binding by arabinose binding protein
♦
Contribution of ligand desolvation to binding thermodynamics of ligand-protein interactions
♦
Contributions to the change in heat capacity occurring on ligand-binding to the major urinary protein
♦
The beta
2
m folding free energy landscape
Lars Jeuken
♦
Electrodes for redox-active membrane proteins
Peter Knight
♦
Structural studies of the motor protein dynein
♦
Structure and properties of regulated myosin 5
Peter Knowles
♦
Two metals are better than one:
E. coli
amine oxidase
♦
Second co-ordination sphere residues in galactose oxidase: tryptophan 290
Mike McPherson
♦
Two metals are better than one:
E. coli
amine oxidase
♦
Second co-ordination sphere residues in galactose oxidase: tryptophan 290
♦
Recombinant production of peptidic bionanomaterials
Adam Nelson
♦
Directed evolution of new enzyme activities
♦
Applications of synthetic organic chemistry to biological problems
♦
Uses of RNA aptamers in molecular biology
Peter Olmsted
♦
Theoretical and computational studies of mechanical unfolding of proteins
Emanuele Paci
♦
Theoretical and computational studies of mechanical unfolding of proteins
♦
Molecular mechanisms of dextran and pectin extension
Simon Phillips
♦
Two metals are better than one:
E. coli
amine oxidase
♦
Second co-ordination sphere residues in galactose oxidase: tryptophan 290
♦
Structure and function of AhrC, the arginine transcription factor from
Bacillus subtilis
♦
The structure of the complex between Bacteriophage T7 Endonuclease I and a synthetic Holliday Junction
♦
Crystal structure of the response regulator VicR DNA-binding domain
♦
X-ray crystallographic analysis of GehD lipase: a potential virulence factor
Staphylococcus epidermidis
infection
♦
Structure determination of a 59 kDa fragment of the DNA-cleavage domain of topoisomerase IV from
Staphylococcus aureus
♦
Uses of RNA aptamers in molecular biology
♦
Assembly of ssRNA viruses: The role(s) of the package during packaging.
Mary Phillips-Jones
♦
In vitro
studies of sensor kinase and response regulator proteins of the Prr two-component signal transduction pathway in
Rhodobacter sphaeroides
♦
Crystal structure of the response regulator VicR DNA-binding domain
Sheena Radford
♦
Mechanical unfolding of proteins using dynamic force spectroscopy
♦
Early states during protein folding
♦
Single molecule protein folding and kinetics
♦
Investigating fibril structure and assembly using mass spectrometry
♦
Determining the mechanism of bacterial fibre assembly using non-covalent electrospray ionisation mass spectrometry
♦
The beta
2
m folding free energy landscape
♦
Molecular mechanisms of dextran and pectin extension
♦
Uses of RNA aptamers in molecular biology
Neil Ranson
♦
Assembly of ssRNA viruses: The role(s) of the package during packaging.
David Rowlands
♦
Targeting the functions of viral proteins with RNA aptamers
♦
Uses of RNA aptamers in molecular biology
D. Alastair Smith
♦
Mechanical unfolding of proteins using dynamic force spectroscopy
♦
Early states during protein folding
♦
Single molecule protein folding and kinetics
♦
Molecular mechanisms of dextran and pectin extension
♦
The design and construction of magnetic tweezers, and the investigation of fibrin clots
♦
Mapping ATP-Dependent Activation at a Sigma54 Promoter
Peter Stockley
♦
Applications of synthetic organic chemistry to biological problems
♦
Structure and function of AhrC, the arginine transcription factor from
Bacillus subtilis
♦
Uses of RNA aptamers in molecular biology
♦
Bacteriophage and virus-like particles as scaffolds for the fabrication of nano-scale devices.
♦
Viruses and virus-like particles as nanoscale delivery systems on a molecular railroad.
♦
Assembly of ssRNA viruses: The role(s) of the package during packaging.
♦
Mapping ATP-Dependent Activation at a Sigma54 Promoter
Nicola Stonehouse
♦
Targeting the functions of viral proteins with RNA aptamers
♦
Investigating the molecular interactions of the phi-29 DNA packaging motor
♦
Assembly of ssRNA viruses: The role(s) of the package during packaging.
Chris Thomas
♦
Molecular mechanism of Staphylococcal plasmid transfer
♦
Structure determination of a 59 kDa fragment of the DNA-cleavage domain of topoisomerase IV from
Staphylococcus aureus
Neil Thomson
♦
Convergent transcription studied at the single molecule level by AFM
♦
The design and construction of magnetic tweezers, and the investigation of fibrin clots
John Trinick
♦
Titin
♦
Electron microscopy of intact tissues and cells
♦
Automated electron microscopy with Leginon
David Westhead
♦
Bioinformatics applied to protein structure and function analysis, and systems biology
Adrian Whitehouse
♦
Identification of the ribonucleoprotein complex required for efficient export of herpesvirus intronless mRNAs
♦
Development of a herpesvirus-based bionanosubmarine
♦
Repressosome formation and disruption regulates the KSHV latent-lytic switch
Andy Wilson
♦
Synthesis of alpha-helix mimetics: inhibitors of protein-protein interactions
Astbury Seminars 2006
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Astbury Publications 2006
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