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The Astbury Centre for Structural Molecular Biology
Annual report 2009
INDEX TO THE 2009 REPORT
The full 2009 report can be downloaded as an 6.7MB pdf file
here
.
Individual reports can be downloaded as pdf files using the links below
Director's statement for 2009
Download
Alison Ashcroft
♦
Biomolecular mass spectrometry
♦
Characterisation of the Mhp1 hydantoin transport protein
♦
Protein-surface recognition using synthetic agents
Stefan Auer
♦
Simulating the self assembly and nucleation of peptides into amyloid fibrils
Steve Baldwin
♦
Insights into membrane protein function from molecular modelling
♦
Characterisation of the Mhp1 hydantoin transport protein
♦
Biomimetic production of precise nanomagnetic particles using magnetic bacteria and their biomineralisation proteins
John Barr
♦
Repair of essential terminal sequences by a negative stranded RNA virus
Alan Berry
♦
Development of LC-MS-MS assays for the directed evolution and characterisation of aldolase enzymes
David Brockwell
♦
Unravelling complexity in the energy landscape of proteins
♦
Exploring the folding energy landscape of immunity protein 7
♦
Mechanical response of collagen fibrils measured by atomic force microscopy
Stan Burgess
♦
Structural studies of the motor proteins dynein and myosin
♦
Influence of lever structure on myosin 5a walking
Rongjun Chen
♦
Responsive biomaterials for medical applications
Lorna Dougan
♦
Single molecule characterisation of protein folding and dynamics
Thomas Edwards
♦
The molecular basis for cellular asymmetry
♦
Protein-surface recognition using synthetic agents
Colin Fishwick
♦
Characterisation of the Mhp1 hydantoin transport protein
♦
Structure based design of inhibitors of human and
Plasmodium falciparum dihydroorotate
dehydrogenase
Stephen Griffin
♦
Targeting viral ion channels for therapy
♦
Studies on hepatitis C virus replication and pathogenesis
♦
NMR solution structure of the hepatitis C virus p7 ion channel
♦
Structural studies of innate immune signalling proteins and viral oncogenes
Sarah Harris
♦
Biomolecular mass spectrometry
Mark Harris
♦
Targeting viral ion channels for therapy
♦
Studies on hepatitis C virus replication and pathogenesis
♦
NMR solution structure of the hepatitis C virus p7 ion channel
Peter Henderson
♦
Biomolecular mass spectrometry
♦
Characterisation of the Mhp1 hydantoin transport protein
♦
Electrodes to study membrane proteins
♦
Activation and inhibition of purified intact membrane sensor kinases involved in virulence and antibiotic resistance in
Enterococcus faecalis
Eric Hewitt
♦
Fibril fragmentation in amyloid assembly and cytotoxicity
Steve Homans
♦
Conformational changes during β2-microglobulin amyloid assembly
♦
NMR solution structure of the hepatitis C virus p7 ion channel
♦
Fibril fragmentation in amyloid assembly and cytotoxicity
♦
Structural investigation of a fibronectintype III domain tandem from A-band titin
♦
Studies on bacterial toxins
Nigel Hooper
♦
Proteolysis and protein:protein interactions in neurodegenerative diseases
♦
Biophysics of lipid bilayers
Lars Jeuken
♦
Electrodes to study membrane proteins
Peter Knight
♦
A stable single alpha-helix can act as a lever in myosin
♦
Influence of lever structure on myosin 5a walking
Andrew Macdonald
♦
Structural studies of innate immune signalling proteins and viral oncogenes
Kenneth McDowall
♦
The yin and yang of gene expression
Adam Nelson
♦
Development of LC-MS-MS assays for the directed evolution and characterisation of aldolase enzymes
Peter Olmsted
♦
Biophysics of lipid bilayers
Emanuele Paci
♦
Simulations are instrumental in interpreting single-molecule experiments and determine free-energy landscapes of proteins
Mark Parsons
♦
Structure based design of inhibitors of human and
Plasmodium falciparum dihydroorotate
dehydrogenase
Arwen Pearson
♦
NMR solution structure of the hepatitis C virus p7 ion channel
♦
Structural studies of innate immune signalling proteins and viral oncogenes
♦
Terahertz spectroscopy of single crystal proteins
♦
Studies on bacterial toxins
♦
Mechanistic study of an ADP-dependent kinase
Mary Phillips-Jones
♦
Activation and inhibition of purified intact membrane sensor kinases involved in virulence and antibiotic resistance in
Enterococcus faecalis
Sheena Radford
♦
Biomolecular mass spectrometry
♦
Conformational changes during β2-microglobulin amyloid assembly
♦
Exploring the folding energy landscape of immunity protein 7
♦
Fibril fragmentation in amyloid assembly and cytotoxicity
♦
Towards a structure of β2-microglobulin amyloid fibrils
♦
Mechanical response of collagen fibrils measured by atomic force microscopy
Neil Ranson
♦
Studies on bacterial toxins
Sarah S Staniland
♦
Biomimetic production of precise nanomagnetic particles using magnetic bacteria and their biomineralisation proteins
Peter Stockley
♦
Biomolecular mass spectrometry
Nicola Stonehouse
♦
Biomolecular mass spectrometry
Chris Thomas
♦
Induced bending of a plasmid origin of replication by its cognate replication initiator protein, RepD, and the helicase PcrA
Neil Thomson
♦
Induced bending of a plasmid origin of replication by its cognate replication initiator protein, RepD, and the helicase PcrA
♦
Mechanical response of collagen fibrils measured by atomic force microscopy
John Trinick
♦
Shape and flexibility in the titin 11-domain super-repeat
♦
Structural investigation of a fibronectintype III domain tandem from A-band titin
♦
Influence of lever structure on myosin 5a walking
Roman Tuma
♦
Structure of self-assembling bacteriochlorophyll nanostructures
W. Bruce Turnbull
♦
Studies on bacterial toxins
Stuart Warriner
♦
Development of LC-MS-MS assays for the directed evolution and characterisation of aldolase enzymes
♦
Protein-surface recognition using synthetic agents
Michael Webb
♦
Mechanistic study of an ADP-dependent kinase
♦
Protein-surface recognition using synthetic agents
Adrian Whitehouse
♦
Identification of the ribonucleoprotein complex required for efficient export and translation of herpesvirus intronless mRNAs
♦
Repressosome formation and disruption regulates the KSHV latent-lytic switch
Andy Wilson
♦
Biomolecular mass spectrometry
♦
Protein-surface recognition using synthetic agents
Dejian Zhou
♦
A pH-driven, fast-responding DNA hydrogel
Astbury Seminars 2009
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Astbury Publications 2009
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