Astbury Centre for Structural Molecular Biology
Annual Report 2004

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INDEX TO THE 2004 REPORT

The full 2004 report can be downloaded as an 16MB pdf file here.

Individual reports can be downloaded as pdf files using the links below

Director's statement for 2004 Download
Andy Baron Analytical centrifuge facility
Alan Berry Structure-guided engineering of N-acetylneuraminic acid lyase
Structural studies of thermostable mutants of fructose-1, 6-bisphosphate aldolase
Conformation dynamics and catalysis of aldolase studied by NMR
Alison Ashcroft Mass spectrometry facility
Investigating the structure of monomeric and fibrillar beta-2m by mass spectrometry
David Brockwell The dynamic properties of single biomolecules
Mechanically unfolding the small, topologically simple protein L
John Findlay Vacuolar ATPase
Mark Harris Studies on the Hepatitis C Virus non-structural NS5A protein
Peter Henderson Electrodes for redox-active membrane proteins
Membrane sensory proteins in bacteria: how sensor kinases sense and respond to environmental signals in pathogenic and other bacteria
Eric Hewitt Investigation into the role of lysosomal proteolysis in Dialysis Related Amyloidosis
Julian Hiscox Biophysical characterisation of the coronavirus nucleoprotein
Cellular characterisation of the coronavirus nucleoprotein- delineating cell cycle control and nucleolar targeting
Steve Homans Conformation dynamics and catalysis of aldolase studied by NMR
NMR facility
Dynamics in the unfolded state of beta2-microglobulin
Identification of a new monosaccharide in Mycobacterium tuberculosis lipoarabinomannan
Thermodynamics of binding of small hydrophobic ligands to the major urinary protein
Relating protein dynamics to the thermodynamics of ligand binding in arabinose binding protein
Dynamics of the MS2 coat protein
Brownian allostery in proteins
RichardJackson Computational molecular modelling of protein structure and function
Studies on the Hepatitis C Virus non-structural NS5A protein
Structural modelling of protein-DNA interactions
Searchable database containing comparisons of ligand binding sites at the molecular level for the discovery of similarities in protein function
Flexligdock: A flexible ligand protein docking tool
Predicting protein-protein interactions
Strategies for ACE2 structure-based inhibitor design
Lars Jeuken Electrodes for redox-active membrane proteins
Arnout Kalverda Conformation dynamics and catalysis of aldolase studied by NMR
NMR facility
Dynamics in the unfolded state of beta2-microglobulin
Relating protein dynamics to the thermodynamics of ligand binding in arabinose binding protein
Jeff Keen Proteomics and allied technologies
Peter Knight Fleximers of the dynein motor protein
Regulated conformation of myosin 5
Brownian allostery in proteins
Peter Knowles Engineering substrate specificity in galactose oxidase
Inhibitor studies with copper amine oxidases
Kenneth McDowell Establishing links in the regulation of antibiotic production
Structure-led studies of a nuclease central to RNA decay and processing
Tom McLeish The dynamic properties of single biomolecules
Brownian allostery in proteins
Mike McPherson Engineering substrate specificity in galactose oxidase
Inhibitor studies with copper amine oxidases
Adam Nelson Structure-guided engineering of N-acetylneuraminic acid lyase
Development of regulated RNA aptamers as tools for in vivo post-genomic analysis.
Emmanuele Paci Mechanically unfolding the small, topologically simple protein L
Martin Parker Effective sampling of protein conformation space: Exploring local structure propensities
Simon Phillips Structural studies of thermostable mutants of fructose-1, 6-bisphosphate aldolase
Crystallographic studies of a type IV topoisomerase from Staphylococcus aureus
Crystal structures of bacteriophage MS2 coat protein mutants complexed with Q-beta RNA stemloop operators a proposed discrimination mechanism for the binding of RNA operators by related phages.
Towards the structure of a bacteriophage T7 endonuclease I / Holliday junction complex
Crystal structure of human keto-hexokinase and its complexes with fructose and a nucleotide analogue.
Thermodynamics of binding of small hydrophobic ligands to the major urinary protein
Structure and function of mammalian scavenger receptors
Brownian allostery in proteins
Inhibitor studies with copper amine oxdiases
Mary Phillips-Jones Membrane sensory proteins in bacteria: how sensor kinases sense and respond to environmental signals in pathogenic and other bacteria
Vas Ponnambalam Structure and function of mammalian scavenger receptors
Membrane dynamics and remodelling by endothelial cells
Sheena Radford UVRR studies of fast protein folding initiated by microsecond mixing
The dynamic properties of single biomolecules
Mechanically unfolding the small, topologically simple protein L
Investigation into the role of lysosomal proteolysis in Dialysis Related Amyloidosis
Dynamics in the unfolded state of beta2-microglobulin
Ultra-rapid folding of the B domain of Staphylococcal protein A
Tailoring the folding mechanisms of the four helix bundle proteins Im7 and Im9
Investigating the structure of monomeric and fibrillar beta2m by mass spectrometry
Amyloid under the atomic force microscope
David Rowlands Using in vitro selection to investigate RNA - protein interactions in picornaviruses
Alastair Smith UVRR studies of fast protein folding initiated by microsecond mixing
The dynamic properties of single biomolecules
Mechanically unfolding the small, topologically simple protein L
Single molecule spectroscopy of a mechano-chemical motor controlling transcriptional initiation
Ultra-rapid folding of the B domain of Staphylococcal protein A
Amyloid under the atomic force microscope
Peter Stockley Analytical centrifuge facility
Single molecule spectroscopy of a mechano-chemical motor controlling transcriptional initiation
Development of regulated RNA aptamers as tools for in vivo post-genomic analysis
Crystal structures of bacteriophage MS2 coat protein mutants complexed with Qbeta RNA stemloop operators a proposed discrimination mechanism for the binding of RNA operators by related phages
Dynamics of the MS2 coat protein
Brownian allostery in proteins
Nicola Stonehouse Investigating the affinity of molecular interactions of the phi-29 packaging motor
Using in vitro selection to investigate RNA - protein interactions in picornaviruses
Crystal structures of bacteriophage MS2 coat protein mutants complexed with Qbeta RNA stemloop operators a proposed discrimination mechanism for the binding of RNA operators by related phages
Dynamics of the MS2 coat protein
Chris Thomas Molecular mechanism of Staphylococcal plasmid transfer
DNA:DNA interactions mediate sequence specificity in the termination of plasmid replication
Crystallographic studies of a type IV topoisomerase from Staphylococcus aureus
Neil Thomson Convergent transcription studied using the atomic force microscope
Sub-molecular resolution of globular proteins using amplitude modulation atomic force microscopy
Amyloid under the atomic force microscope
John Trinick Class I myosins
Class VI myosins
Titin
Vacuolar ATPase
Bruce Turnbull Identification of a new monosaccharide in Mycobacterium tuberculosis lipoarabinomannan
David Westhead Machine learning to predict gene and protein function
Reconstruction and analysis of biochemical networks
Storage and analysis of microarray data
Computational molecular modelling of protein structure and function
Adrian Whitehouse Herpes viral-host cell interactions which regulate viral gene expression
Astbury Seminars 2004 Download
Astbury Publications 2004 Download