Astbury Centre for Structural Molecular Biology
Annual Report 2005

INDEX TO THE 2005 REPORT

The full 2005 report can be downloaded as an 14MB pdf file here.

Individual reports can be downloaded as pdf files using the links below

Director's statement for 2005 Download
Steven Baldwin Functional characterization of the novel human equilibrative nucleoside transporter (hENT3) located in intracellular membranes
Chronic myeloid leukaemia: the role of Bcr-Abl-induced abnormalities in glucose transport regulation.
The Membrane Protein Structure Initiative
Alan Berry Directed evolution of enzymes with synthetically useful activities
Conformation dynamics and catalysis of aldolase studied by NMR
Structural studies of thermostable FBP-aldolases created by directed evolution.
Applications of synthetic organic chemistry to biological problems.
Crystal structure of N-acetylneuraminic acid lyase mutants.
Alison Ashcroft Mass spectrometry facility
Structure and redox-dependednt regulation of a fasciclin I domain protein (Fdp) involved in in vitro adherence of Rhodobacter sphaeroides.
Determining the mechanism of bacterial fibre assembly using non-covalent electrospray ionisation mass spectrometry.
David Brockwell Single molecule protein folding using FRET
Mechanical unfolding of proteins using dynamic force spectroscopy.
Thomas Edwards Structural biology of Pumilo and Puf family RNA binding proteins
John Findlay The Membrane Protein Structure Initiative
Mark Harris Studies on the functions of hepatitis C virus proteins.
Studies on the HIV-1 Nef protein.
Peter Henderson The hydantoin transport protein from Microbacterium liquefaciens
Electrodes for redox-active membrane proteins
The Membrane Protein Structure Initiative
Eric Hewitt Investigation into the initiation of fibril formation in Dialysis Related Amyloidosis
Julian Hiscox Characterization of the severe acute respiratory coronavirus RNA binding protein
Delineation of nucleolar trafficking signals
Interaction of coronaviruses with the nucleolus
Interaction of coronaviruses with the cell cycle
Steve Homans Conformation dynamics and catalysis of aldolase studied by NMR
  Relating protein dynamics to the thermodynamics of ligand binding in arabinose binding protein
Thermodynamics of binding of small hydrophobic ligands to the major urinary protein
Dynamics of the MS2 coat protein
The NMR facility
Folding and aggregation of beta-2-microglobulin
Richard Jackson Software tools for docking and structure based drug design
Searchable database containing comparisons of ligand binding sites at the molecular level for the discovery of similarities in protein function
Identification of novel ACE2 inhibitors by structure-based pharmacophore modelling and virtual screening
Predicting protein-protein interactions
Applications of synthetic organic chemistry to biological problems
Molecular modelling of protein structural behaviour
Lars Jeuken Electrodes for redox-active membrane proteins
Arnout Kalverda Conformation dynamics and catalysis of aldolase studied by NMR
Relating protein dynamics to the thermodynamics of ligand binding in arabinose binding protein
The NMR facility
Discovery of stable, single a-helices in myosins
Folding and aggregation of beta2-microglobulin
Jeff Keen Structure and redox-dependent regulation of a fasciclin I domain protein (Fdp) involved in in vitro adherence of Rhodobacter sphaeroides
Peter Knight Discovery of stable, single a-helices in myosins
Kenneth McDowell Dissecting the functions of a transcriptional activator of antibiotic production by disrupting its 'reading head' to create a dominant-negative mutant
Structure-led studies of a nuclease central to RNA decay and processing
Tom McLeish Dynamic allostery of the dynein stalk coiled coil
High dimensional models of protein folding
Mike McPherson High yield recombinant production of self-assembling peptides in microbes and plants
Two metals are better than one: E. coli amine oxidase
Galactose oxidase, processing, substrate specificity and directed evolution studies
The Membrane Protein Structure Initiative
Adam Nelson Directed evolution of enzymes with synthetically useful activities
Applications of synthetic organic chemistry to biological problems.
Crystal structure of N-acetylneuraminic acid lyase mutants.
Peter Olmsted Theoretical and computational studies of mechanical unfolding of proteins
Emmanuele Paci Theoretical and computational studies of mechanical unfolding of proteins
Martin Parker Computational modelling of amyloidogenic peptides
Folding and aggregation of beta-2-microglobulin
Simon Phillips Structural studies of thermostable FBP-aldolases created by directed evolution.
Thermodynamics of binding of small hydrophobic ligands to the major urinary protein
Two metals are better than one: E. coli amine oxidase
Galactose oxidase, processing, substrate specificity and directed evolution studies
Towards the structure of a bacteriophage T7 endonuclease I / Holliday Junction complex
Crystallographic studies of RNA binding discrimination between bacteriophages MS2 and Qbeta.
Crystal structure of N-acetylneuraminic acid lyase mutants
Determination of the structure of a type IV topoisomerase from Staphylococcus aureus
The Membrane Protein Structure Initiative
Mary Phillips-Jones Structure and redox-dependent regulation of a fasciclin I domain protein (Fdp) involved in in vitro adherence of Rhodobacter sphaeroides
Sheena Radford Protein folding mechanisms
Single molecule protein folding using FRET
Determining the mechanism of bacterial fibre assembly using non-covalent electrospray ionisation mass spectrometry
Folding and aggregation of beta-2-microglobulin
Mechanical unfolding of proteins using dynamic force spectroscopy
Investigation into the initiation of fibril formation in dialysis related amyloidosis
Exploring the assembly pathways of beta-2-microglobulin amyloidosis.
David Rowlands Studies on the functions of hepatitis C virus proteins.
RNA aptamers that inhibit the replicase enzyme of foot and mouth disease virus
Alastair Smith Protein folding mechanisms
Single molecule protein folding using FRET
Mechanical unfolding of proteins using dynamic force spectroscopy
Exploring the assembly pathways of beta-2-microglobulin amyloidosis.
Peter Stockley Dynamics of the MS2 coat protein
Applications of synthetic organic chemistry to biological problems
Crystallographic studies of RNA binding discrimination between bacteriophages MS2 and Qbeta.
Nicola Stonehouse RNA aptamers that inhibit the replicase enzyme of foot and mouth disease virus
Investigating the affinity of molecular interactions of the phi29 packaging motor
Chris Thomas Determination of the structure of a type IV topisomerase from Staphylococcus aureus
Molecular mechanism of Staphylococcal plasmid transfer
Neil Thomson Exploring the assembly pathways of beta-2-microglobulin amyloidosis
Atomic force microscopy of DNA structure and interactions
John Trinick Titin
Myosin XVIII
Class VI myosins
Bruce Turnbull Structural and enzymatic studies on a novel substituent of Mycobacterium tuberculosis lipoarabinomannan
Atomic force microscopy of DNA structure and interactions
David Westhead Machine learning to predict gene and protein function
Storage and analysis of microarray data
Molecular modelling of protein structural behaviour
Reconstruction and analysis of biochemical networks
Adrian Whitehouse Herpes virus-host cell interactions which regulate viral gene expression
Andrew Wilson Design and synthesis of ligands for distruption of protein-protein interactions
Astbury Seminars 2005 Download
Astbury Publications 2005 Download