... understanding life in molecular detail

Astbury Report 2007

INDEX TO THE 2007 REPORT
The full 2007 report can be downloaded as an 15.8MB pdf file here.
Individual reports can be downloaded as pdf files using the links below
Director's statement for 2007 Download
Alison Ashcroft Subunit specificity in P pilus assembly studied by mass spectrometry
Mass spectrometry research group
Photo-induced cross-linking studies of amyloid
Determining a molecular pathway for formation of a T=3 viral capsid using ESI-MS and ESI-IMS-MS
Chaperone-assisted pilus assembly revealed in atomic detail by molecular dynamics
Steve Baldwin Elucidating the folding mechanism of a bacterial outer membrane protein
3D reconstruction of mammalian septin filaments
Alan Berry New tools for the enzymatic synthesis of complex oligosaccharides.
Structural analysis of engineered N-acetyl-neuraminic acid lyase
David Brockwell Using force to investigate the stability of proteins and their complexes
Elucidating the folding mechanism of a bacterial outer membrane protein
Exploring the effect of mechanical forces on biopolymers through theory, models and novel experimental techniques
Stan Burgess Structural studies of the motor protein dynein
Structure of switched-off smooth muscle myosin
Thomas Edwards A beta-sheet interaction interface directs the tetramerisation of the Miz-1 POZ domain
The structure of the Pumilio homology domain of murine Pum2
Structural studies of innate immune signalling proteins
Synthesis of alpha-helix mimetics: inhibitors of protein-protein interactions
Stephen Griffin The p7 ion channel of hepatitis C virus (HCV) as a therapeutic target
Studies on the hepatitis C virus non-structural proteins NS2 and NS5A
Mark Harris The p7 ion channel of hepatitis C virus (HCV) as a therapeutic target
Studies on the HIV-1 Nef protein
Peter Henderson Structural genomics of bacterial membrane proteins
A systems approach for investigating bacterial signal sensing mechanisms: expression, purification and activities of the entire family of sensor kinases of Enterococcus faecalis
Electrodes for redox-active membrane proteins
Eric Hewitt Investigation into the role of macrophages in formation and degradation of beta-2-microglobulin amyloid fibrils
Julian Hiscox Interaction of coronaviruses with the host cell
The role of phosphorylation in the coronavirus nucleocapsid protein
Development of a herpesvirus-based bionanosubmarine
Steve Homans Understanding the driving forces behind molecular affinity in model protein systems
The NMR solution structure and dynamics of K7: A poxvirus protein that adopts a Bcl-2 fold
Nigel Hooper Role of the prion protein in Alzheimers disease
Lars Jeuken Electrodes for redox-active membrane proteins
Peter Knight Structure of switched-off smooth muscle myosin
Load-dependent mechanism of nonmuscle myosin 2
Andrew Macdonald Structural studies of innate immune signalling proteins
Kenneth McDowall The end is not always in sight: multiple single-stranded segments can stimulate rapid cleavage by Escherichia coli RNase E
5-prime sensing stimulates the decay of functional mRNA transcripts in vivo
Two-dimensional gel electrophoresis for identifying nucleic acid-binding proteins
Mike McPherson Recombinant production of self-assembling and therapeutic peptides in biological expression systems
Peripheral calcium influences cofactor biogenesis in E. coli amine oxidase
Adam Nelson New tools for the enzymatic synthesis of complex oligosaccharides.
Structural analysis of engineered N-acetyl-neuraminic acid lyase
The diversity-oriented synthesis of natural product-like molecules of unprecedented scaffold diversity
Peter Olmsted Exploring the effect of mechanical forces on biopolymers through theory, models and novel experimental techniques
Emanuele Paci Subunit specificity in P pilus assembly studied by mass spectrometry
Protein folding landscapes from computer simulations
Exploring the effect of mechanical forces on biopolymers through theory, models and novel experimental techniques
Exploring the folding energy landscape for immunity proteins
Chaperone-assisted pilus assembly revealed in atomic detail by molecular dynamics
Arwen Pearson Structural analysis of engineered N-acetyl-neuraminic acid lyase
Structural studies of innate immune signalling proteins
Developing new single crystal spectrophotometers for structural biology
Simon Phillips Structural analysis of engineered N-acetyl-neuraminic acid lyase
Understanding the driving forces behind molecular affinity in model protein systems
Peripheral calcium influences cofactor biogenesis in E. coli amine oxidase
X-ray structures of two manganese superoxide dismutases from Caenorhabditis elegans
The crystal structure of bacteriophage T7 endonuclease I resolving a Holliday Junction
Mary Phillips-Jones Structural genomics of bacterial membrane proteins
A systems approach for investigating bacterial signal sensing mechanisms: expression, purification and activities of the entire family of sensor kinases of Enterococcus faecalis
Sheena Radford Subunit specificity in P pilus assembly studied by mass spectrometry
Using force to investigate the stability of proteins and their complexes
Elucidating the folding mechanism of a bacterial outer membrane protein
Investigation into the role of macrophages in formation and degradation of beta-2-microglobulin amyloid fibrils
High-dimensional models of protein folding
Exploring the effect of mechanical forces on biopolymers through theory, models and novel experimental techniques
Photo-induced cross-linking studies of amyloid
Exploring the folding energy landscape for immunity proteins
Fibril growth kinetics of beta-2-microglobulin
The nucleation-dependent self-assembly mechanism of beta-2-microglobulin
RNA aptamers against disease related proteins
Chaperone-assisted pilus assembly revealed in atomic detail by molecular dynamics
Neil Ranson Electron microscopy studies of yeast prion Ure2p fibrils
RNA packaging and capsid assembly in bacteriophage MS2
David Rowlands The p7 ion channel of hepatitis C virus (HCV) as a therapeutic target
Picornavirus cell entry: genome-release and membrane penetration
Aphthovirus cell entry: characterization of equine rhinitis A virus and its low pH derived empty particle
Using RNA aptamers to study the replication of foot-and-mouth disease virus
Peter Stockley Dynamic allostery in proteins
Determining a molecular pathway for formation of a T=3 viral capsid using ESI-MS and ESI-IMS-MS
RNA aptamers against disease related proteins
RNA packaging and capsid assembly in bacteriophage MS2
Nicola Stonehouse Determining a molecular pathway for formation of a T=3 viral capsid using ESI-MS and ESI-IMS-MS
Targeting the functions of the Human Papilloma Virus 16 oncoproteins with RNA aptamers
Using RNA aptamers to study the replication of foot-and-mouth disease virus
Chris Thomas Understanding the recruitment and processivity of the staphylococcal helicase PcrA in the context of plasmid replication
Neil Thomson Understanding the recruitment and processivity of the staphylococcal helicase PcrA in the context of plasmid replication
Atomic force microscopy applications to living bacteria
John Trinick 3D reconstruction of mammalian septin filaments
3D Reconstruction of a large protease complex from Haemonchus contortus
Roman Tuma Structure and self-assembly of antennae pigments in green photosynthetic bacteria
Structure, mechanism and application of viral RNA packaging motors
Bruce Turnbull Inhibiting bacterial toxin adhesion using protein aggregation
Stuart Warriner The diversity-oriented synthesis of natural product-like molecules of unprecedented scaffold diversity
Synthesis of alpha-helix mimetics: inhibitors of protein-protein interactions
David Westhead Gene function and network prediction
Adrian Whitehouse Identification of the ribonucleoprotein complex required for efficient export of herpesvirus intronless mRNAs
Development of a herpesvirus-based bionanosubmarine
Repressosome formation and disruption regulates the KSHV latent-lytic switch
Andy Wilson Photo-induced cross-linking studies of amyloid
Synthesis of alpha-helix mimetics: inhibitors of protein-protein interactions
Astbury Seminars 2007 Download
Astbury Publications 2007 Download