... understanding life in molecular detail

Astbury Report 2008

INDEX TO THE 2008 REPORT
The full 2008 report can be downloaded as an 15.8MB pdf file here.
Individual reports can be downloaded as pdf files using the links below
Director's statement for 2008 Download
Alison Ashcroft Biomolecular mass spectrometry â?? simultaneous mass measurements & cross-sectional areas
HDX-ESI-MS reveals enhanced conformational dynamics of the amyloidogenic protein beta2-microglobulin upon release from the MHC-1
Design and synthesis of small molecule probes for the study of protein recognition
John Barr Stoichiometry and specificity of RNA binding by the bunyavirus nucleocapsid protein
Alan Berry Structural analysis of engineered N-acetyl-neuraminic acid lyase
David Brockwell Exploring proteins using force as a denaturant
Stan Burgess Structural studies of the motor protein dynein
Conserved structure of compact myosin 2 in species separated by at least 600 million years of independent evolution
Thomas Edwards Structural studies of innate immune signalling proteins
Stephen Griffin Studies on the hepatitis C virus non-structural proteins NS2 and NS5A
Hepatitis C virus (HCV) particle assembly as a therapeutic target
Sarah Harris Biomolecular mass spectrometry â?? simultaneous mass measurements & cross-sectional areas
Mark Harris Studies on the hepatitis C virus non-structural proteins NS2 and NS5A
Hepatitis C virus (HCV) particle assembly as a therapeutic target
Peter Henderson Biomolecular mass spectrometry â?? simultaneous mass measurements & cross-sectional areas
Molecular mechanism of substrate translocation by a nucleoside-cation-symport-1 family transport protein
Expression, purification and activities of the entire family of membrane sensor kinases of Enterococcus faecalis and studies of quorum sensor FsrC and essential sensor VicK
Electrodes for redox-active membrane proteins
Julian Hiscox Development of a herpesvirus-based bionanosubmarine
Steve Homans Studies on the hepatitis C virus non-structural proteins NS2 and NS5A
Poxvirus K7 protein adopts a Bcl-2 fold and interacts with Human DEAD box RNA helicase DDX3
Thermodynamic characterisation of a hydrophilic ligand-protein interaction
Nigel Hooper Role of protein interactomes in Alzheimerâ??s disease
Coarse-grained simulations of lipid bilayers: the role of composition and the nature of interactions with detergents and peptides
Lars Jeuken Electrodes for redox-active membrane proteins
Peter Knight Conserved structure of compact myosin 2 in species separated by at least 600 million years of independent evolution
Andrew Macdonald Structural studies of innate immune signalling proteins
Kenneth McDowall Aptamers selections and bioinformatics combined extend the AtrA regulon to cell morphogenesis and nutrient uptake
A new perspective on the initiation of bacterial mRNA degradation
Mike McPherson Recombinant production of nanostructured self-assembling and therapeutic peptides for tissue engineering
Structural and functional studies of oxidases
Adam Nelson Structural analysis of engineered N-acetyl-neuraminic acid lyase
Synthesis and chemical biology of natural product-like small molecules
Peter Olmsted Coarse-grained simulations of lipid bilayers: the role of composition and the nature of interactions with detergents and peptides
Emanuele Paci Free-energy surfaces of proteins from reversible folding simulations
Exploring the energy landscape of proteins using mechanical forces: simulations and theory
Arwen Pearson Structural analysis of engineered N-acetyl-neuraminic acid lyase
Studies on the hepatitis C virus non-structural proteins NS2 and NS5A
Structural studies of innate immune signalling proteins
Mechanistic characterisation of an ADP-dependent kinase
Structural and functional studies of oxidases
Simon Phillips Structural analysis of engineered N-acetyl-neuraminic acid lyase
Structural and functional studies of oxidases
Mary Phillips-Jones Expression, purification and activities of the entire family of membrane sensor kinases of Enterococcus faecalis and studies of quorum sensor FsrC and essential sensor VicK
Sheena Radford Biomolecular mass spectrometry â?? simultaneous mass measurements & cross-sectional areas
HDX-ESI-MS reveals enhanced conformational dynamics of the amyloidogenic protein beta2-microglobulin upon release from the MHC-1
Systematic analysis of the self-assembly mechanism of 2-microglobulin into amyloid fibrils
Elucidating a generic mechanism of β2-microglobulin amyloid assembly at neutral pH
Exploring the folding energy landscape for immunity proteins Im7 and Im9
Single molecule protein folding and kinetics
Design and synthesis of small molecule probes for the study of protein recognition
Exploring proteins using force as a denaturant
David Rowlands The FMDV replication complex
Hepatitis C virus (HCV) particle assembly as a therapeutic target
Peter Stockley Biomolecular mass spectrometry â?? simultaneous mass measurements & cross-sectional areas
Synthesis and chemical biology of natural product-like small molecules
Nicola Stonehouse Biomolecular mass spectrometry â?? simultaneous mass measurements & cross-sectional areas
Targeting the functions of the Human Papilloma Virus 16 oncoproteins with RNA aptamers.
The FMDV replication complex
Chris Thomas The staphylococcal PcrA helicase requires the action of both the replication initiator RepD and SSB proteins to unwind the small plasmid pCERoriD
Cross-specificity in the dimerisation of pT181 family Rep proteins
Neil Thomson The staphylococcal PcrA helicase requires the action of both the replication initiator RepD and SSB proteins to unwind the small plasmid pCERoriD
Applications of atomic force microscopy to DNA
John Trinick Cryo-electron microscopy of the vacuolar ATPase motor reveals mechanical and regulatory complexity
Structure of a bacterial Type-I DNA methyltransferase with a bound antirestriction protein from phage T7 using electron microscopy
Roman Tuma Dynamics of viral RNA dependent RNA polymerase studied by hydrogen-deuterium exchange and mass spectrometry
Bruce Turnbull Structural and enzymatic studies on a novel substituent of Mycobacterium tuberculosis lipoarabinomannan
Stuart Warriner Mechanistic characterisation of an ADP-dependent kinase
Design and synthesis of small molecule probes for the study of protein recognition
Synthesis and chemical biology of natural product-like small molecules
Michael Webb Mechanistic characterisation of an ADP-dependent kinase
David Westhead The reconstruction and evolution of metabolic networks
Bioinformatics: predicting disease causing mutations and genes
Adrian Whitehouse Identification of the ribonucleoprotein complex required for efficient export and translation of herpesvirus intronless mRNAs
Development of a herpesvirus-based bionanosubmarine
Repressosome formation and disruption regulates the KSHV latent-lytic switch
Andy Wilson Biomolecular mass spectrometry â?? simultaneous mass measurements & cross-sectional areas
Design and synthesis of small molecule probes for the study of protein recognition
Dejian Zhou pH-driven DNA nanostructures and devices
Astbury Seminars 2008 Download
Astbury Publications 2008 Download