... understanding life in molecular detail

Astbury Report 2011

INDEX TO THE 2011 REPORT
The full 2011 report can be downloaded as an 11.6MB pdf file here.
Individual reports can be downloaded as pdf files using the links below
Director's statement for 2011 Download
Alison Ashcroft Biomolecular mass spectrometry
Investigating the mechanisms of amyloid formation
Designed inhibitors of protein-protein interactions
Stefan Auer Applying classical nucleation theory to describe amyloid fibril formation
Steve Baldwin Novel ligands for the Na+-hydantoin membrane transport protein, Mhp1
Exploring protein folding energy landscapes
Biomimetic production of precise nanomagnetic particles using magnetic bacteria and their biomineralisation proteins
Paul Beales DNA-directed assembly of giant Janus vesicles
Alan Berry QM/MM modelling of the reaction mechanism and chemical incorporation of non natural amino acids into the active site of N-acetylneuraminic acid lyase
Robin Bon Label-free electrochemical detection of enzymatic activity using microarrays
David Brockwell Breaking apart protein complexes by force
Exploring protein folding energy landscapes
Rongjun Chen Manipulating the interaction of pH-responsive polymers with lipid membranes for intracellular drug delivery
Simon Connell Biophysical theory and simulation of stratum corneum lipid bilayers
Lorna Dougan Understanding the cryoprotective action of glycerol
Thomas Edwards Kinked beta-strands mediate high-affinity recognition of mRNA targets by the germ-cell regulator DAZL
Structural and mechanistic insights into the FusB family of fusidic acid resistance proteins
Designed inhibitors of protein-protein interactions
Stephen Evans Novel spectroelectrochemical methods to study redox enzymes
Biomimetic production of precise nanomagnetic particles using magnetic bacteria and their biomineralisation proteins
Colin Fishwick de novo ligand design of novel bacterial RNA polymerase inhibitors
Identification and optimisation of small molecule modulators of protein targets as chemical probes and therapeutics
Novel ligands for the Na+-hydantoin membrane transport protein, Mhp1
Richard Foster Identification and optimisation of small molecule modulators of protein targets as chemical probes and therapeutics
Structure-guided drug design leads to highly potent inhibitors of the hepatitis C virus p7 ion channel
Stephen Griffin Structure-guided drug design leads to highly potent inhibitors of the hepatitis C virus p7 ion channel
Sarah Harris High performance computer simulations of biomacromolecules
Mark Harris Structure-guided drug design leads to highly potent inhibitors of the hepatitis C virus p7 ion channel
Peter Henderson Novel ligands for the Na+-hydantoin membrane transport protein, Mhp1
Deuteration of solid-state NMR samples for structural measurements with weakly-binding ligands and membrane proteins
TROSY solution-state NMR with a large α-helical membrane protein
Novel spectroelectrochemical methods to study redox enzymes
Eric Hewitt Investigating β2m-amyloid associated cytotoxicity in primary monocytes and osteoarticular cells
Steve Homans TROSY solution-state NMR with a large α-helical membrane protein
Structural and mechanistic insights into the FusB family of fusidic acid resistance proteins
Nigel Hooper Role of prion protein in the production and mechanism of action of amyloid-beta oligomers in Alzheimerâ??s disease
Lars Jeuken Novel spectroelectrochemical methods to study redox enzymes
Mike McPherson Establishing novel non-antibody binding probe libraries
Adam Nelson QM/MM modelling of the reaction mechanism and chemical incorporation of non natural amino acids into the active site of N-acetylneuraminic acid lyase
Identification and optimisation of small molecule modulators of protein targets as chemical probes and therapeutics
Peter Olmsted Biophysical theory and simulation of stratum corneum lipid bilayers
Alex ONeill de novo ligand design of novel bacterial RNA polymerase inhibitors
Structural and mechanistic insights into the FusB family of fusidic acid resistance proteins
Emanuele Paci Free energy landscapes for disordered polypeptides, proteins under mechanical force and molecular machines
Dynamic structural science: Developing tools to probe molecular mechanism
A new experimental approach to probe global protein dynamics
Arwen Pearson QM/MM modelling of the reaction mechanism and chemical incorporation of non natural amino acids into the active site of N-acetylneuraminic acid lyase
Structure-guided drug design leads to highly potent inhibitors of the hepatitis C virus p7 ion channel
Dynamic structural science: Developing tools to probe molecular mechanism
A new experimental approach to probe global protein dynamics
Synthesis and application of stable phosphohistidine analogues
Michelle Peckham The cytoskeleton and molecular motors, from molecular mechanisms to super-resolution imaging
Mary Phillips-Jones Interactions of the intact FsrC membrane histidine kinase with its pheromone ligand GBAP revealed through synchrotron radiation circular dichroism (SRCD)
Sheena Radford Breaking apart protein complexes by force
Investigating β2m-amyloid associated cytotoxicity in primary monocytes and osteoarticular cells
Exploring protein folding energy landscapes
Investigating the mechanisms of amyloid formation
Sarah S Staniland Biomimetic production of precise nanomagnetic particles using magnetic bacteria and their biomineralisation proteins
Chris Thomas Enhanced stability and activity of a truncated replication initiator protein
Neil Thomson How does the size of the tip affect measurements in atomic force microscopy?
Darren Tomlinson Establishing novel non-antibody binding probe libraries
Synthesis and application of stable phosphohistidine analogues
John Trinick Structure and operation of the DNA-translocating type I DNA restriction enzymes
Roman Tuma Nucleic acid translocation by a hexameric molecular motor at single molecule level
Stuart Warriner Designed inhibitors of protein-protein interactions
Michael Webb Dynamic structural science: Developing tools to probe molecular mechanism
Synthesis and application of stable phosphohistidine analogues
Adrian Whitehouse Identification of the ribonucleoprotein complex required for efficient viral RNA processing in oncogenic herpesviruses
Designed inhibitors of protein-protein interactions
Andy Wilson Designed inhibitors of protein-protein interactions
Astbury Seminars 2011 Download
Astbury Publications 2011 Download