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Astbury Report 2013
Astbury Report 2013
INDEX TO THE 2013 REPORT
The full 2013 report can be downloaded as an 6MB pdf file
here
.
Individual reports can be downloaded as pdf files using the links below
Director's statement for 2013
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Alison Ashcroft
♦
Biomolecular mass spectrometry
♦
Using ion mobility mass spectrometry to probe amyloid formation
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Nucleocapsid protein structures from orthobunyaviruses reveal insight into ribonucleoprotein architecture and RNA polymerization
♦
Mechanistic insights into the material and cytotoxic properties of amyloid fibril polymorphs
♦
Developing inhibitors of protein-protein interactions
Stefan Auer
♦
Phase behaviour and transitions in complex biological systems
John Barr
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Nucleocapsid protein structures from orthobunyaviruses reveal insight into ribonucleoprotein architecture and RNA polymerization
♦
Identification of host cell ion channel modulators as new anti-viral targets
Paul Beales
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DNA-directed assembly of lipid nanodiscs into BioNanoStack architectures
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Cytochrome c can permeabilize model mitochondrial membranes
Alan Berry
♦
Improving on Nature: protein engineering and design
Robin Bon
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Solid phase synthesis of functionalised SAM-forming alkanethiol-oligoethyleneglycols
David Brockwell
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Unravelling mechano-allostery using the atomic force microscope
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In vitro studies of outer membrane protein assembly
Simon Connell
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Structural analysis of BTB-domain proteins implicated in human cancer
Kevin Critchley
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Solid phase synthesis of functionalised SAM-forming alkanethiol-oligoethyleneglycols
James Duce
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The involvement of β-amyloid precursor protein in neuronal iron homeostasis in dementia
Thomas Edwards
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Nucleocapsid protein structures from orthobunyaviruses reveal insight into ribonucleoprotein architecture and RNA polymerization
♦
Developing inhibitors of protein-protein interactions
Colin Fishwick
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Optimising inhibitors for Toxoplasma gondii enoyl reductase
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Identification and optimisation of small molecule as chemical probes or as therapeutics
Richard Foster
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Identification and optimisation of small molecule as chemical probes or as therapeutics
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Structure-guided drug design targeting the release of hepatitis C virus particles
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Studies of small DNA tumour viruses that cause disease in humans
Adrian Goldman
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The mechanism of a unique protozoan parasite primary ion pump
Stephen Griffin
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Structure-guided drug design targeting the release of hepatitis C virus particles
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Studies of small DNA tumour viruses that cause disease in humans
Mark Harris
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Structure-guided drug design targeting the release of hepatitis C virus particles
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Studies on hepatitis C virus replication and pathogenesis
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Identification of host cell ion channel modulators as new anti-viral targets
Peter Henderson
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Ligand binding to a novel drug resistance protein measured using circular dichroism
Eric Hewitt
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Mechanistic insights into the material and cytotoxic properties of amyloid fibril polymorphs
Lars Jeuken
♦
Protein-protein interaction regulates the direction of catalysis and electron transfer in a redox enzyme complex
Sergei Krivov
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Understanding complex dynamics at atomistic resolution
Andrew Macdonald
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Studies of small DNA tumour viruses that cause disease in humans
Jamel Mankouri
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Identification of host cell ion channel modulators as new anti-viral targets
Kenneth McDowall
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Breaking dogmas: direct entry by RNase E and pervasive transcription
Stephen Muench
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Optimising inhibitors for Toxoplasma gondii enoyl reductase
Adam Nelson
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Improving on Nature: protein engineering and design
♦
Identification and optimisation of small molecule as chemical probes or as therapeutics
♦
Development of tools and approaches to facilitate more systematic exploration of lead-like chemical space
♦
Developing inhibitors of protein-protein interactions
Alex ONeill
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Structural and mechanistic insights into the FusB family of fusidic acid resistance proteins
Emanuele Paci
♦
Understanding the mechanism and regulation of the Vacuolar ATPase
Arwen Pearson
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Improving on Nature: protein engineering and design
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Structure-guided drug design targeting the release of hepatitis C virus particles
♦
Developing new tools for time-resolved structural biology
Michelle Peckham
♦
Investigating how mutations in cardiac myosin cause heart and skeletal muscle disease
Sheena Radford
♦
Using ion mobility mass spectrometry to probe amyloid formation
♦
Unravelling mechano-allostery using the atomic force microscope
♦
In vitro studies of outer membrane protein assembly
♦
Mechanistic insights into the material and cytotoxic properties of amyloid fibril polymorphs
♦
Developing inhibitors of protein-protein interactions
Neil Ranson
♦
Nucleocapsid protein structures from orthobunyaviruses reveal insight into ribonucleoprotein architecture and RNA polymerization
David Rowlands
♦
Structure-guided drug design targeting the release of hepatitis C virus particles
Peter Stockley
♦
Mechanistic insights into the material and cytotoxic properties of amyloid fibril polymorphs
Nicola Stonehouse
♦
Nucleocapsid protein structures from orthobunyaviruses reveal insight into ribonucleoprotein architecture and RNA polymerization
Chris Thomas
♦
Alteration of the metal ion binding site of RepSTK1
Neil Thomson
♦
DNA secondary structure imaged by AFM
John Trinick
♦
Understanding the mechanism and regulation of the Vacuolar ATPase
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Studies of the troponin complex in relaxed muscle thin filaments
Roman Tuma
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Structure and dynamics of hexameric helicases â?? from atomic details to single molecule biophysics
Bruce Turnbull
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Development of tools and approaches to facilitate more systematic exploration of lead-like chemical space
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Methods for re-engineering bacterial toxins
Stuart Warriner
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Development of tools and approaches to facilitate more systematic exploration of lead-like chemical space
♦
Developing new tools for time-resolved structural biology
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Developing inhibitors of protein-protein interactions
Michael Webb
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Developing new tools for time-resolved structural biology
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Methods for re-engineering bacterial toxins
Adrian Whitehouse
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Studies of small DNA tumour viruses that cause disease in humans
♦
Identification of host cell ion channel modulators as new anti-viral targets
♦
Identification of the ribonucleoprotein complex required for efficient viral RNA processing in oncogenic herpesviruses
Andy Wilson
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Developing inhibitors of protein-protein interactions
Stephanie Wright
♦
Structural analysis of BTB-domain proteins implicated in human cancer
Dejian Zhou
♦
A magnetic nanoparticle-enzyme based ultrasensitive diagnostic assay
Anastasia Zhuravleva
♦
Structural and mechanistic insights into the FusB family of fusidic acid resistance proteins
♦
The relationship between conformational flexibility, landscape roughness, sequence variability and function for Hsp70 molecular chaperones
Astbury Seminars 2013
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Astbury Publications 2013
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