... understanding life in molecular detail

Astbury Report 2014

INDEX TO THE 2014 REPORT
The full 2014 report can be downloaded as a pdf file here.
Individual reports can be downloaded as pdf files using the links below
Director's statement for 2014 Download
Alison Ashcroft Modulation of biologically relevant processes using small molecules
Probing Bunyavirus N protein oligomerisation using mass spectrometry
Novel methods for screening and classifying small molecule inhibitors of protein aggregation
Biomolecular mass spectrometry
Alison Baker Plant Chemical Genetics
Peroxisomal ABC transporters
Peroxisome protein import
Steve Baldwin Phosphate Signalling and Transport
Peroxisomal ABC transporters
John Barr Host cell ion channels as new anti-viral targets
Probing Bunyavirus N protein oligomerisation using mass spectrometry
The crystal structure of the M2-1 protein from human respiratory syncytial virus (HRSV) and its function as an anti-terminator
Paul Beales β2-microglobulin amyloid fibrils disrupt membranes enriched in endosomal lipids and inhibit protein degradation by lysosomes
Mechanistic insights into the role of lipid composition in the anticancer activity of an antimicrobial peptide
Alan Berry Improving on Nature: protein engineering and design
Peroxisome protein import
Robin Bon Targeted contrast agents for imaging of inflammatory markers
Alex Breeze Modulation of biologically relevant processes using small molecules
Monitoring New Delhi Metallo--lactamase activity in live bacterial cells using NMR spectroscopy: new methods for antibacterials drug discovery
David Brockwell Novel methods for screening and classifying small molecule inhibitors of protein aggregation
Physics of life in extreme environments
In vitro folding and remodelling of outer membrane proteins
Stan Burgess Flexibility within the heads of muscle myosin-2 molecules
Joe Cockburn Cargo binding and regulation of kinesins
Simon Connell Mechanistic insights into the role of lipid composition in the anticancer activity of an antimicrobial peptide
Lorna Dougan Physics of life in extreme environments
James Duce The involvement of β-amyloid precursor protein proteolytic processing in neuronal iron homeostasis in dementia
Thomas Edwards Modulation of biologically relevant processes using small molecules
Probing Bunyavirus N protein oligomerisation using mass spectrometry
The crystal structure of the M2-1 protein from human respiratory syncytial virus (HRSV) and its function as an anti-terminator
Colin Fishwick The first small-molecule inhibitors of members of the ribonuclease E family
Richard Foster Targeted contrast agents for imaging of inflammatory markers
Novel methods for screening and classifying small molecule inhibitors of protein aggregation
Identification and optimisation of small molecule inhibitors as chemical tools
Stephen Griffin Viruses as combined anti-cancer and antiviral immunotherapies
Mark Harris Host cell ion channels as new anti-viral targets
Studies on hepatitis C virus replication and pathogenesis
Sarah Harris Understanding the mechanism and regulation of the Vacuolar ATPase
Computational Biophysics
Peter Henderson Kinetic dissection of the Na+-coupled binding of hydantoin to purified Mhp1
Eric Hewitt β2-microglobulin amyloid fibrils disrupt membranes enriched in endosomal lipids and inhibit protein degradation by lysosomes
Lars Jeuken Hybrid protein-nanoparticle layers for photovoltaics
Peter Knight Flexibility within the heads of muscle myosin-2 molecules
Sergei Krivov Fep1d: a script for the analysis of reaction coordinates
Andrew Macdonald Studies of small DNA tumour viruses that cause disease in humans
Jamel Mankouri Host cell ion channels as new anti-viral targets
Kenneth McDowall The first small-molecule inhibitors of members of the ribonuclease E family
Direct entry by RNase E is a common pathway for the degradation and processing of RNA in Escherichia coli
Stephen Muench Understanding the mechanism and regulation of the Vacuolar ATPase
Phosphate Signalling and Transport
Adam Nelson Modulation of biologically relevant processes using small molecules
Development of tools and approaches to facilitate the discovery of bioactive small molecules
Improving on Nature: protein engineering and design
Alex ONeill Structural and mechanistic insights into the FusB family of fusidic acid resistance proteins
Emanuele Paci In silico studies of proteins: folding, mechanics, dynamics and self-assembly
Michelle Peckham Cytoskeletal motors, muscle and single alpha helical domains, intriguing structural elements in proteins
Sheena Radford Modulation of biologically relevant processes using small molecules
Novel methods for screening and classifying small molecule inhibitors of protein aggregation
β2-microglobulin amyloid fibrils disrupt membranes enriched in endosomal lipids and inhibit protein degradation by lysosomes
Targeting transient and lowly-populated species during amyloid assembly
In vitro folding and remodelling of outer membrane proteins
Neil Ranson β2-microglobulin amyloid fibrils disrupt membranes enriched in endosomal lipids and inhibit protein degradation by lysosomes
Ryan Seipke Heterologous production of kitamycin by Escherichia coli
Peter Stockley Targeting transient and lowly-populated species during amyloid assembly
Domain movements of the enhancer-dependent sigma factor drive DNA delivery into the RNA polymerase active site
Nicola Stonehouse Probing Bunyavirus N protein oligomerisation using mass spectrometry
Studies on hepatitis C virus replication and pathogenesis
Darren Tomlinson Targeted contrast agents for imaging of inflammatory markers
John Trinick Understanding the mechanism and regulation of the Vacuolar ATPase
Cryo-electron tomography of isolated muscle Z-discs
Roman Tuma Domain movements of the enhancer-dependent sigma factor drive DNA delivery into the RNA polymerase active site
Bruce Turnbull An engineered glycoprotein inhibitor of cholera toxin
Patricija van Oosten-Hawle Transcellular stress signalling: How proteotoxic stress is communicated between different tissues in C.elegans
Stuart Warriner Modulation of biologically relevant processes using small molecules
Development of tools and approaches to facilitate the discovery of bioactive small molecules
Plant Chemical Genetics
An engineered glycoprotein inhibitor of cholera toxin
Peroxisome protein import
Adrian Whitehouse Host cell ion channels as new anti-viral targets
Andy Wilson Modulation of biologically relevant processes using small molecules
Stephanie Wright Crystal structures of heterodimeric POZ domains
Anastasia Zhuravleva Molecular-level regulation of molecular chaperones
Structural and mechanistic insights into the FusB family of fusidic acid resistance proteins
Astbury Seminars 2014 Download
Astbury Publications 2014 Download