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Astbury Report 2015

INDEX TO THE 2015 REPORT
The full 2015 report can be downloaded as an 18.3 MB pdf file here.
Individual reports can be downloaded as pdf files using the links below
Director's statement for 2015 Download
Peter Adams Bio-inspired model membranes and light-harvesting nanomaterials
Alison Ashcroft Biomolecular mass spectrometry and structural proteomics
Mass spectrometry to study the structure and function of membrane proteins
Combining in vitro and in vivo methods for the identification and classification of novel small molecule inhibitors of protein aggregation
Alison Baker Engineering novel natural products and binding motifs
John Barr The crystal structure of the Hazara virus nucleocapsid protein
Modulation of potassium channels inhibits bunyavirus infection
Richard Bayliss Back-to-back dimerization reverses autoinhibition of protein kinases
Paul Beales Formulation of poorly water soluble drugs using lipoprotein-mimetic nanodiscs
Alan Berry Protein engineering of aldolases
Engineering novel natural products and binding motifs
Robin Bon Natural and synthetic flavonoid modulation of TRPC5 channels
Alex Breeze NMR and biophysical insights into mechanisms of auto-inhibition in fibroblast growth-factor receptor 1 kinase
Inhibition of protein-protein interactions using small molecules
David Brockwell Developments in single molecule force spectroscopy
Mass spectrometry to study the structure and function of membrane proteins
Combining in vitro and in vivo methods for the identification and classification of novel small molecule inhibitors of protein aggregation
Stan Burgess Cryo-EM of cytoplasmic dynein motors during movement on microtubules
Joe Cockburn Cargo binding and regulation of kinesins
Lorna Dougan Developments in single molecule force spectroscopy
James Duce Neuronal iron homeostasis in neurodegeneration
Thomas Edwards The crystal structure of the Hazara virus nucleocapsid protein
ABC-F proteins mediate antibiotic resistance through ribosomal protection
Inhibition of protein-protein interactions using small molecules
Colin Fishwick Natural and synthetic flavonoid modulation of TRPC5 channels
(±) cis-bisamido epoxides as a novel series of potent FXIII-A inhibitors
Richard Foster Development of a novel small molecule anticoagulant with minimal bleeding risk
Structure-guided design of novel inhibitors targeting the drug resistant M2 proton channel from pandemic swine influenza
The exploration of biologically-relevant chemical space
Combining in vitro and in vivo methods for the identification and classification of novel small molecule inhibitors of protein aggregation
Adrian Goldman Elucidating the complete reaction cycle for membrane-bound pyrophosphatases
Stephen Griffin Structure-guided design of novel inhibitors targeting the drug resistant M2 proton channel from pandemic swine influenza
Sarah Harris Reaching the mesoscale in bio-molecular simulations with fluctuating finite element analysis
Mark Harris Studies on virus replication and pathogenesis
Peter Henderson Mass spectrometry to study the structure and function of membrane proteins
Lars Jeuken Molecular mechanism by which a hydrogen reducing enzyme protects itself from damage by radical oxygen species
Single enzyme experiments reveal a long-lifetime proton leak state in a proton-pumping enzyme
Peter Knight Cryo-EM of cytoplasmic dynein motors during movement on microtubules
Sergei Krivov Nonparametric variational optimization of reaction coordinates
John Ladbury Receptor tyrosine kinase signalling in the absence of growth factor stimulation
Andrew Macdonald Studies of small DNA tumour viruses that cause disease in humans
Inhibition of protein-protein interactions using small molecules
Jamel Mankouri Modulation of potassium channels inhibits bunyavirus infection
Kenneth McDowall The activation of RNase E by binding of structured RNAs to an allosteric site
Mike McPherson Going green: bio-inspired approaches to inorganic material synthesis
Developing a toolbox of Adhiron reagents to inhibit protein-protein interactions in disease
Stephen Muench Understanding the mechanism and regulation of the Vacuolar ATPase
Adam Nelson Protein engineering of aldolases
The exploration of biologically-relevant chemical space
Inhibition of protein-protein interactions using small molecules
Alex ONeill ABC-F proteins mediate antibiotic resistance through ribosomal protection
Emanuele Paci In silico studies of proteins: folding, mechanics, dynamics and self-assembly
Michelle Peckham Imaging the cytoskeleton in health and disease
Sheena Radford Mass spectrometry to study the structure and function of membrane proteins
Combining in vitro and in vivo methods for the identification and classification of novel small molecule inhibitors of protein aggregation
Neil Ranson Mechanisms of assembly and genome packaging in an RNA virus revealed by high-resolution cryo-EM
Direct evidence for a RNA packaging signal-mediated virus assembly mechanism
David Rowlands Direct evidence for a RNA packaging signal-mediated virus assembly mechanism
Ryan Seipke Coordinate regulation of antimycin and candicidin biosynthesis
Peter Stockley The influence of two-dimensional organization on peptide conformation
Direct evidence for a RNA packaging signal-mediated virus assembly mechanism
Avian reovirus non-structural protein ?NS acts as an RNA chaperone and assists genome segment assortment
Paul Taylor Unexpected evolutionary proximity of eukaryotic and cyanobacterial enzymes responsible for biosynthesis of retinoic acid and its oxidation
Darren Tomlinson Developing a toolbox of Adhiron reagents to inhibit protein-protein interactions in disease
Inhibition of protein-protein interactions using small molecules
John Trinick Understanding the mechanism and regulation of the Vacuolar ATPase
Titin ruler hypothesis not refuted
Roman Tuma Single enzyme experiments reveal a long-lifetime proton leak state in a proton-pumping enzyme
Direct evidence for a RNA packaging signal-mediated virus assembly mechanism
Avian reovirus non-structural protein ?NS acts as an RNA chaperone and assists genome segment assortment
Andrew Tuplin The role of structured RNA in early virus replication events
Bruce Turnbull Multivalent inhibitors of carbohydrate-binding proteins
Structural basis for regulation of bacterial pantothenate biosynthesis
Stuart Warriner Engineering novel natural products and binding motifs
The exploration of biologically-relevant chemical space
Inhibition of protein-protein interactions using small molecules
Michael Webb Formulation of poorly water soluble drugs using lipoprotein-mimetic nanodiscs
Developing a toolbox of Adhiron reagents to inhibit protein-protein interactions in disease
Structural basis for regulation of bacterial pantothenate biosynthesis
David Westhead Dynamic gene regulatory networks drive hematopoietic specification and differentiation
Cross-platform gene expression classifier of Burkitt’s and diffuse large B-cell lymphoma
Adrian Whitehouse Novel antiviral strategies for human tumour viruses
Stephanie Wright Regulating protein ubiquitination by high-order oligomerisation
Dejian Zhou Multifunctional nanomedicines for efficient, targeted cancer treatment
Anastasia Zhuravleva Molecular mechanisms of the unfolded protein response
Astbury Seminars 2015 Download
Astbury Publications 2015 Download