... understanding life in molecular detail

Astbury Report 2016

INDEX TO THE 2016 REPORT
The full 2016 report can be downloaded as an 4 MB pdf file here.
Individual reports can be downloaded as pdf files using the links below
Director's statement for 2016 Download
Peter Adams Efficiency of energy trapping by Light-Harvesting proteins
Alison Ashcroft Biomolecular mass spectrometry and structural proteomics
Insights into the folding mechanisms of periplasmic chaperones
Lateral opening in the intact beta-barrel assembly machinery captured by cryo-EM
John Barr Host-cell interactions of Risk Group 4 viruses
Understanding the requirement for ion channel activity during virus infection
Richard Bayliss The many (interacting) faces of Aurora-A kinase
Paul Beales Bio-inspired model membranes and light-harvesting nanomaterials
Alan Berry Protein engineering of aldolases
Engineering novel natural products and binding motifs
Robin Bon Economical and scalable synthesis of 6-amino-2-cyanobenzothiazole
Alex Breeze Structural studies of auto-inhibition and mutational activation in fibroblast growthfactor receptors
Designed inhibitors of protein-protein interactions
David Brockwell The physics of life in extreme environments
Insights into the folding mechanisms of periplasmic chaperones
Lateral opening in the intact beta-barrel assembly machinery captured by cryo-EM
Joe Cockburn Structural biology of the microtubule cytoskeleton
Lorna Dougan The physics of life in extreme environments
James Duce Ferroptosis as a new cell death pathway involved in neurodegeneration
Thomas Edwards Host-cell interactions of Risk Group 4 viruses
ABC-F proteins mediate antibiotic resistance through ribosomal protection
Designed inhibitors of protein-protein interactions
Colin Fishwick Structure-based design of inhibitors of metallo beta-lactamases: rescuing our current antibiotics
New small molecule inhibitors of T. gondii bc1: towards a cure for toxoplasmosis
Development of a novel small molecule anticoagulant with minimal bleeding risk
Electron microscopy of membrane proteins to underpin structure guided inhibitor
Juan Fontana Understanding how the fusion protein of Herpes Simplex Virus-1, gB, drives fusion between the virus and the host cell membranes
Richard Foster Development of a novel small molecule anticoagulant with minimal bleeding risk
Novel antiviral strategies for human herpesviruses
Adrian Goldman Structural and functional studies of membrane pyrophosphatases
Stephen Griffin Causative and curative viruses in human cancer
Sarah Harris Fluctuating Finite Element Analysis - A Simulation Package for Biomolecular Simulation of Electron Microscopy Data Base (EMDB) Structures
Insights into the folding mechanisms of periplasmic chaperones
Glyn Hemsworth Towards a better understanding of oxidative biomass deconstruction
Peter Henderson Production, purification and characterization of proteins of the proteobacterial acinetobacter chlorhexidine efflux, PACE family involved in antimicrobial resistance
Eric Hewitt An integrated approach to the study of cellular interactions with amyloid
Lars Jeuken Bio-inspired model membranes and light-harvesting nanomaterials
A model membrane system to mimic folded cristae of mitochondria and thylakoid stacks of chloroplast
Sergei Krivov Optimal reaction coordinates
John Ladbury Receptor tyrosine kinase signalling in the absence of growth factor stimulation
Jamel Mankouri Host-cell interactions of Risk Group 4 viruses
Understanding the requirement for ion channel activity during virus infection
Kenneth McDowall An improved binary cloning system for studying the mechanistic biology of plants
Mike McPherson Positive allosteric modulation of TRPV1 using Affimer reagents
Stephen Muench Bio-inspired model membranes and light-harvesting nanomaterials
New small molecule inhibitors of T. gondii bc1: towards a cure for toxoplasmosis
Electron microscopy of membrane proteins to underpin structure guided inhibitor
Adam Nelson Protein engineering of aldolases
Engineering novel natural products and binding motifs
Unified synthetic approaches to explore biologically-relevant chemical space
Designed inhibitors of protein-protein interactions
Alex ONeill ABC-F proteins mediate antibiotic resistance through ribosomal protection
Emanuele Paci The physics of life in extreme environments
Proteins under the computational microscope: folding, disorder, mechanics, dynamics and self-assembly
Michelle Peckham How myosin 10 travels to filopodia tips
Sheena Radford An integrated approach to the study of cellular interactions with amyloid
Insights into the folding mechanisms of periplasmic chaperones
The molecular details of amyloid fibril-glycosaminoglycan binding
Lateral opening in the intact beta-barrel assembly machinery captured by cryo-EM
Co-operative mechanism of protein translocation through Sec machinery
Neil Ranson Lateral opening in the intact beta-barrel assembly machinery captured by cryo-EM
Ryan Seipke Coordinate regulation of antimycin and candicidin biosynthesis
Jung-uk Shim Study of sensory neurons of C.elegans using a microfluidic device
Paul Taylor Simvastatin and fluvastatin interact with human gap junction gamma-3 protein
Darren Tomlinson Positive allosteric modulation of TRPV1 using Affimer reagents
John Trinick Regulation of muscle contraction by titin and myosin binding protein C
Roman Tuma Co-operative mechanism of protein translocation through Sec machinery
Andrew Tuplin The role of structured RNA in early virus replication events
Bruce Turnbull Probing multivalent protein-carbohydrate interactions using compact, polyvalent glycan-quantum dot and Förster resonance energy transfer
Patricija van Oosten-Hawle Transcellular stress signalling: How proteotoxic stress is communicated between different tissues in C.elegans
Stuart Warriner Economical and scalable synthesis of 6-amino-2-cyanobenzothiazole
Designed inhibitors of protein-protein interactions
David Westhead Transcellular stress signalling: How proteotoxic stress is communicated between different tissues in C.elegans
Adrian Whitehouse Novel antiviral strategies for human herpesviruses
Andy Wilson Designed inhibitors of protein-protein interactions
Megan Wright Profiling protein lipidation in parasites with chemical tools
Dejian Zhou Probing multivalent protein-carbohydrate interactions using compact, polyvalent glycan-quantum dot and Förster resonance energy transfer
Astbury Seminars 2016 Download
Astbury Publications 2016 Download