... understanding life in molecular detail

Astbury Report 2017

INDEX TO THE 2017 REPORT
The full 2017 report can be downloaded as an 6 MB pdf file here.
Individual reports can be downloaded as pdf files using the links below
Director's statement for 2017 Download
Peter Adams Investigation of the photosynthetic protein Light-Harvesting Complex II: protection against photo-damage and artificial light harvesting
Alison Ashcroft The role of fluid flow in causing protein aggregation
Non-covalent complexes studied by mass spectrometry: Examples of amyloid assembly and membrane protein structure and function
Effects of periplasmic chaperones and membrane thickness on BamA-catalysed outer-membrane protein folding
John Barr Studies of small DNA tumour viruses that cause disease in humans
Richard Bayliss Targeting the cancer supercontroller Myc through inhibition of Aurora-A
Paul Beales Repurposing ESCRT-III machinery for fabrication of eukaryote-like artificial cells
Electron microscopy of membrane proteins to underpin structure guided inhibitor design
Alan Berry Enzyme engineering of aldolases
Engineering novel natural products and binding motifs
Robin Bon Affimer-based immunosensor of an environmental contaminant
Alex Breeze Using NMR to study large RNAs at ultra-high field using direct detection of 15N
David Brockwell The role of fluid flow in causing protein aggregation
The physics of life in extreme environments
Folded globular proteins as hydrogel Lego bricks
Effects of periplasmic chaperones and membrane thickness on BamA-catalysed outer-membrane protein folding
Joe Cockburn Structural biology of the microtubule cytoskeleton
Lorna Dougan The physics of life in extreme environments
Folded globular proteins as hydrogel Lego bricks
Understanding the stability of Single Alpha Helical (SAH) domains
Thomas Edwards Protein-surface recognition using designed molecules
Stephen Evans Patterned and polymer supported lipid membranes for controlling protein confinement and orientation
Colin Fishwick Inhibition of D-Ala:D-Ala ligase through a phosphorylated form of the antibiotic Dcycloserine
Development of a novel small molecule anticoagulant with minimal bleeding risk
Electron microscopy of membrane proteins to underpin structure guided inhibitor design
chemical genomics approach to drug reprofiling in oncology: antipsychotic drug risperidone as a potential adenocarcinoma treatment
Juan Fontana Imaging Herpes Simplex Virus life cycle using cryo-electron microscopy
Studies of small DNA tumour viruses that cause disease in humans
Richard Foster Development of a novel small molecule anticoagulant with minimal bleeding risk
Flavivirus small membrane (M) proteins as potential ion channel antiviral targets
Adrian Goldman Affimer proteins inhibit immune complex binding to Fc?RIIIa with high
Stephen Griffin Flavivirus small membrane (M) proteins as potential ion channel antiviral targets
Glyn Hemsworth Towards a better understanding of oxidative biomass deconstruction
Peter Henderson Topological dissection of a protein derived from cysteine accessibility and mass
Eric Hewitt Cellular interactions with amyloid
Lars Jeuken Multilayered lipid membrane stacks for biocatalysis using bacterial membrane extracts
Antreas Kalli Flavivirus small membrane (M) proteins as potential ion channel antiviral targets
The Band 3 anion exchanger in a lipid bilayer
Effects of periplasmic chaperones and membrane thickness on BamA-catalysed outer-membrane protein folding
Sergei Krivov Accurate determination of optimal reaction coordinates from atomistic simulations
John Ladbury Receptor tyrosine kinase signalling in the absence of growth factor stimulation: response to cellular stress
Andrew Macdonald Flavivirus small membrane (M) proteins as potential ion channel antiviral targets
Studies of small DNA tumour viruses that cause disease in humans
Jamel Mankouri Studies of small DNA tumour viruses that cause disease in humans
Stephen Muench Electron microscopy of membrane proteins to underpin structure guided inhibitor design
Adam Nelson Enzyme engineering of aldolases
Engineering novel natural products and binding motifs
Unified synthetic approaches to diverse biologically-relevant molecular scaffolds
Protein-surface recognition using designed molecules
Alex ONeill Revisiting unexploited antibiotics in search of new antibacterial drug candidates
Emanuele Paci Proteins under the computational microscope:
Understanding the stability of Single Alpha Helical (SAH) domains
Michelle Peckham Understanding the stability of Single Alpha Helical (SAH) domains
Sheena Radford The role of fluid flow in causing protein aggregation
Topological dissection of a protein derived from cysteine accessibility and mass
Cellular interactions with amyloid
Non-covalent complexes studied by mass spectrometry: Examples of amyloid assembly and membrane protein structure and function
Effects of periplasmic chaperones and membrane thickness on BamA-catalysed outer-membrane protein folding
Protein translocation dynamics revealed by single molecule fluorescence
Neil Ranson Flavivirus small membrane (M) proteins as potential ion channel antiviral targets
High resolution Cryo-EM to study virus-receptor interactions
A Novel Conserved Assembly Mechanism in ssRNA Viruses
Ralf Richter Controlling multivalent binding through surface chemistry
Ryan Seipke Revisiting unexploited antibiotics in search of new antibacterial drug candidates
Heterologous production of neoantimycins
Jung-uk Shim Heterologous production of neoantimycins Microfluidic droplets enabling study of atmospheric science in a high throughput way
Frank Sobott Liquid-liquid phase separation of RNA-binding proteins
Peter Stockley A Novel Conserved Assembly Mechanism in ssRNA Viruses
Paul Taylor chemical genomics approach to drug reprofiling in oncology: antipsychotic drug risperidone as a potential adenocarcinoma treatment
Darren Tomlinson Affimer-based immunosensor of an environmental contaminant
Protein-surface recognition using designed molecules
John Trinick Titin control of exact myosin filament length in muscle
Roman Tuma A Novel Conserved Assembly Mechanism in ssRNA Viruses
Protein translocation dynamics revealed by single molecule fluorescence
Andrew Tuplin The role of structured RNA in early virus replication events
Bruce Turnbull Multivalent protein-carbohydrate interactions
Dissecting multivalent lectin–glycan recognition using polyvalent glycan-quantum dots based multimodal readout strategy
Patricija van Oosten-Hawle Transcellular stress signalling: How proteotoxic stress is communicated between different tissues in C.elegans
Stuart Warriner Protein-surface recognition using designed molecules
David Westhead Transcellular stress signalling: How proteotoxic stress is communicated between different tissues in C.elegans
Andy Wilson Non-covalent complexes studied by mass spectrometry: Examples of amyloid assembly and membrane protein structure and function
Protein-surface recognition using designed molecules
Megan Wright Chemical probes reveal the mechanism of an inter-kingdom signal
Elton Zeqiraj Assembly, activation and function of BRCC36 deubiquitylating complexes
Dejian Zhou Multivalent protein-carbohydrate interactions
Dissecting multivalent lectin–glycan recognition using polyvalent glycan-quantum dots based multimodal readout strategy
Anastasia Zhuravleva Post-translational allosteric fine-tuning of the molecular chaperone BiP
Astbury Seminars 2017 Download
Astbury Publications 2017 Download