The Astbury Centre for Structural Molecular Biology

Members

Alison Ashcroft Mass spectrometry, Mass Spectrometry Facility Manager

Stefan Auer Computational biophysics, biological self-assembly, peptide and protein aggregation, amyloid formation.

Steve Baldwin Membrane Proteins, Membrane Transport, Signal Transduction, Vesicular Trafficking

John Barr Structural Biology, Viral gene expression

Paul Beales Nanomedicine, Membrane Biophysics, Biomolecular Self-assembly, Biomimetic Adhesion

Alan Berry Protein Engineering, Directed Evolution, Molecular Enzymology, Aldolases

Robin Bon Medicinal & Synthetic Organic Chemistry, Chemical Biology, Chemical Genetics.

David Brockwell Single Molecule Mechanical Unfolding of Proteins and their Complexes

Stan Burgess Cryoelectron microscopy, motor proteins, dynein structure and function

Rongjun Chen Drug Delivery, Stimuli-Responsive Polymers, Biofunctional Nanomaterials

Simon Connell Atomic Force Microscopy, Lipid membranes

Kevin Critchley Self-assembly; Quantum dots, Nanowires, Self-assembled monolayers

Lorna Dougan Single molecule force-clamp spectroscopy, protein folding, neutron diffraction, liquids

Thomas Edwards Structural Biology, RNA:Protein Interactions, Molecular Control of Embryogenesis

Stephen Evans Supported lipid membranes; Bio-templated nanowires and Nanostructured materials.

John Findlay Structure and Mechanism of Action of Membrane Proteins, Receptors and Transport Systems

Colin Fishwick Medicinal chemistry, application of computer-aided methods in drug design and chemical biology

Richard Foster Medicinal chemistry, Computer-aided drug design, High-throughput screening, Chemical biology

Stephen Griffin Hepatitis C virus, p7, ion channel, virus assembly

Mark Harris Structural Studies on HIV-1 Nef Protein

Sarah Harris Molecular dynamics simulation, theoretical biophysics

Peter Henderson Membrane Proteins, Sugar Transport, Antibiotic Resistance

Eric Hewitt Cellular Interactions with Amyloid and Molecular Immunology

Julian Hiscox Viral RNA Binding Proteins

Nigel Hooper Cell biology, proteolysis, Alzheimer

Lars Jeuken Membrane Biology, Metalloenzymes, Biophysics, Electron transfer

Peter Knight Structural Basis of Movement in Cells and Tissues

Andrew MacDonald Structural studies on immune signaling proteins

Kenneth McDowall Macromolecular Interactions in RNA Processing and Decay

Mike McPherson Protein Engineering; Directed Evolution; Copper Oxidases; Protease Inhibitors; Functional Genomics and Proteomics

Stephen Muench Electron microscopy, X-ray crystallography and protein complexes

Adam Nelson Directed evolution, chemical biology, chemical genetics, diversity-oriented synthesis

Alex O'Neill Bacterial resistance to antibiotics; biological characterization of novel antibacterial agents

Peter Olmsted Protein folding/unfolding, protein dynamics, membranes, motility.

Emanuele Paci Computational Biology; Protein Folding; Molecular Dynamics

Arwen Pearson Structural Enzymology and Single Crystal Spectroscopy

Michelle Peckham Bio-imaging, Cell Biology, Muscle structure and differentiation, Molecular Motors

Vas Ponnambalam Structure-Function of Membrane Traffic Regulators, Membrane Binding

Sheena Radford Protein folding, Amyloid disease, New biophysical techniques, Molecular chaperones

Neil Ranson Cryo-EM; Image Processing; Macromolecular structure

Sarah S Staniland Biomineralisation of magnetic nanoparticles in magnetic bacteria

Peter Stockley Self-assembling systems: Protein-nucleic acid regulatory complexes; molecular recognition; gene expression; bionanoscience

Nicola Stonehouse RNA-Protein Interactions in viral systems; RNA aptamers

Chris Thomas Plasmid Biology; Protein-DNA and Protein-Protein Interactions

Neil Thomson Biological Physics, Bionanotechnology, Atomic Force Microscopy (AFM)

Darren Tomlinson siRNA screening – whole and part genome, selection of non-antibody binding reagents, diagnostics and target validation

John Trinick Molecular Motors, Bioelasticity, Giant Proteins, Cryo-electron Microscopy

Roman Tuma Virus, self-assembly, molecular motors, optical tweezers

W. Bruce Turnbull Carbohydrate Chemistry, Isothermal Titration Calorimetry, Molecular Recognition, Multivalent Interactions

Stuart Warriner Automated Synthesis of Oligosaccharides, Chemical Synthesis

Michael Webb Enzymology, biosynthesis, biophysical techniques, chemical biology

David Westhead Bioinformatics

Adrian Whitehouse Oncogenic herpesviruses : virus-host cell interactions

Andy Wilson Synthetic Chemistry; Supramolecular Chemistry; Nanotechnology; Chemical Biology

Dejian Zhou Bionanotechnology, single-molecule Fluorescence, nanoparticle sensor, scanning probe microscopy

Visiting Members

Steve Homans NMR Spectroscopy

Paul Ko Ferrigno Peptide aptamers-protein engineering-artificial antibodies-protein microarrays- cancer

Simon Phillips 

Mary Phillips-Jones Bacterial signalling and response to environmental change; bacterial sensing of antibiotics

Emeritus members

Peter Johnson Molecular Modelling; Methods Development; Organic Synthesis

Peter Knowles Copper Oxidases; Free Radicals; Self-Assembly; Membranes

Tony North Macromolecular Structure

David Rowlands Structure and Replication Strategies of RNA Viruses