... understanding life in molecular detail

Prof Nicola Stonehouse

Virus, molecular interactions, vaccines, aptamers


The Stonehouse group have interests in virology and RNA biology, applying novel approaches to the study of virus replication and assembly

Current major projects include:
  • Use of RNA aptamers to study viral proteins and inhibit their function
  • Viral assembly and vaccine development
  • Viral Replication

The Stonehouse group have interests in virology and RNA biology, applying novel approaches to the study of virus replication and assembly in three main research areas:

1) We have a long-standing interest in picornaviral replication, especially the role of the viral polymerase of foot-and-mouth disease virus. Current projects, funded by the Wellcome Trust and BBSRC include the use of RNA aptamers as novel molecular tools.

2) We also use aptamers for the study of the oncogenes of human papillomavirus (the causative agent of cervical and other cancers).

3) We use structure-based methods in the design of novel vaccines e.g. to polio and EV71. THis work is funded by WHO/Gates foundation and Sanofi Pasteur.

Detailed research programme                  Close ▲
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Professor of Molecular Virology



PhD Leeds and BSc UEA
Professor of Molecular Virology

Garstang 8.53b
School of Molecular and Cellular Biology
0113 343 3102
n.j.stonehouse@leeds.ac.uk

Selected Publications

  1. Herod MR, Ferrer-Orta C, Loundras EA, Ward JC, Verdaguer N, Rowlands DJ, Stonehouse NJ Both Cis- and Trans- Activities of the Foot-and-Mouth Disease Virus 3D Polymerase are Essential for Viral RNA Replication. Journal of virology -, 2016

  2. Kelly JT, De Colibus L, Elliott L, Fry EE, Stuart DI, Rowlands DJ, Stonehouse NJ Potent antiviral agents fail to elicit genetically-stable resistance mutations in either enterovirus 71 or Coxsackievirus A16 Antiviral Research 124 77-82, 2015
    DOI:10.1016/j.antiviral.2015.10.006
     

  3. Holmes K, Shepherd DA, Ashcroft AE, Whelan M, Rowlands DJ, Stonehouse NJ Assembly pathway of hepatitis B core virus-like particles from genetically fused dimers Journal of Biological Chemistry 290 16238-16245, 2015
    DOI:10.1074/jbc.M114.622035
     

  4. CesurÖ, Nicol C, Groves H, Mankouri J, Blair GE, Stonehouse NJ The subcellular localisation of the human papillomavirus (HPV) 16 E7 protein in cervical cancer cells and its perturbation by RNA aptamers Viruses 7 3443-3461, 2015
    DOI:10.3390/v7072780